We found that age at death was correlated with MVP density in the frontal neocortex, Brodmann Area 9 (r = 0.51; p < 0.0001). When performing exploratory analyses to evaluate the association between conventional vascular risk factors (e.g., hypertension, diabetes), cardiovascular diseases (e.g., heart attack, arrhythmia), and cerebrovascular disease (e.g., stroke, transient ischemic attack) we did not find an association between these variables and MVP density. Nor did we detect a specific association between neuropathological (e.g., brain arteriolosclerosis, chronic traumatic encephalopathy) or genetic (e.g., APOE) variables and MVP density. Using a tissue clearing method called SeeDB, we provide 3-dimensional images of MVPs in brain tissue.