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Abstract Details

Application Of Digital Cognition And Pen-based Sketching Tasks In A Chinese Population-Based Cohort.
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
146
To investigate whether imaging markers of cerebral small vessel disease (CSVD) correlates with digital hand-functions in community-dwelling populations.

We developed a simple mental state detection system with multi-channels (Patent NO.: CN 103956171 B). The system can achieve traditional cognitive tests, e.g. Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), trail making test (TMT) Parts A & B as well as spiral test, and so on. The pen-based sketching techniques would enable acquiring of digital hand-function parameters by the system.
A total of 993 participants from the Shunyi study were included. Cognitive functions were measured by application of the simple mental state detection system with multi-channels. Digital hand-function parameters including time of drawing clock, time of drawing cube and time of drawing spiral line were obtained. Burdens of CSVD included brain volumes (brain parenchymal fraction, BPF; white matter fractions, WM fraction; cortical gray matter fraction, cortical GM fraction; and hippocampal fraction), volumes of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds (CMBs) were measured by magnetic resonance imaging (MRI). Multiple linear regression models adjusted by age, sex, and education were used to assess the relationship between CSVD markers and digital hand-function parameters.
BPF was negatively associated with time of drawing cube (β = -0.046, p = 0.0010). WM fraction was associated with associated with time of drawing clock and cube (β = -0.058, p = 0.0020; β = -0.066, p = 0.0005, respectively). However, cortical GM fraction and hippocampal fraction were not associated with digital hand-function parameters. WMH volumes were associated with time of drawing cube (β = 0.065, p = 0.0054). Digital hand-function parameters were not associated with imaging markers of lacunes or CMBs, irrespective of anatomical locations.
Our finding suggested that imaging burdens of CSVD (volumes of parenchymal, WM and WMH) were closely related to digiacl hand-function in community-dwelling populations.
Authors/Disclosures
Ning Su, MD (Peking Union Medical College Hospital)
PRESENTER 		Dr. Su has nothing to disclose.
No disclosure on file
No disclosure on file
Jing Yuan (Peking Union Medical College Hospital) No disclosure on file
No disclosure on file
No disclosure on file
Ming Yao Ming Yao has nothing to disclose.
Li-Ying Cui No disclosure on file
Zheng-Yu Jin No disclosure on file
Shu-Yang Zhang No disclosure on file
Feng Tian No disclosure on file
Yi-Cheng Zhu, MD, PhD (Peking Union Medical College Hospital) Dr. Zhu has nothing to disclose.