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Abstract Details

A Case of Sneddon Syndrome
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
230
Offer an additional differential to include for a young patient with recurrent strokes and skin changes with no obvious risk factors, and provide a case to aid in recognizing when this would be appropriate.
Sneddon Syndrome is a rare autoimmune vasculopathy that affects the blood vessels in the skin and the brain, leading to rashes and recurrent strokes. It can be challenging to diagnose, as its workup may include transient antiphospholipid antibody elevation and abnormalities on skin biopsy, but the workup is frequently negative, at least initially. This presents a unique challenge in stroke workup and typically leads to management of these patients per the guidelines for embolic stroke of unknown source. This can increase the risk of recurrent strokes given many of these patients require long-term anticoagulation.
This is a case of a 33-year-old woman who presented with recurrent strokes and transient ischemic attacks over a two-year period. She underwent an extensive workup including vessel imaging, autoimmune and hypercoagulability laboratory studies, and cardiac monitoring and imaging, all of which was unremarkable besides a transiently elevated antiphospholipid antibody that later resolved. Her diagnosis came when she developed a rash, underwent a skin biopsy, and was diagnosed with livedo racemosa, indicative of an underlying disease.
Based on her age, recurrent strokes, skin biopsy, and transiently elevated antiphospholipid antibody, the patient was diagnosed with Sneddon Syndrome. She was started on anticoagulation with Warfarin and has had no further recurrence.
This case emphasizes the importance of keeping rare diseases in the differential, and it demonstrates an appropriate case in which to consider this. The outcome for this patient highlights the necessity of appropriate management in order to minimize the risk of recurrent strokes.
Authors/Disclosures
Teryn Nogles, MD (Virtua Health)
PRESENTER 		Dr. Nogles has nothing to disclose.
Rachel Aubert, DO (UT Southwestern Medical Center) Dr. Aubert has nothing to disclose.
Daniel Falcao, DO, FÂ鶹´«Ã½Ó³»­ (VCUHS-Neurology Dept) Dr. Falcao has nothing to disclose.