Abstract Details

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Abstract Details

Title Inflammatory amyloid angiopathy: a series of clinical cases and a review of the literature

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 220

Objective

We present a series of probable AAIs based on clinical-radiological criteria treated in a tertiary spanish hospital.

Background

Inflammatory amyloid angiopathy (AAI) is a rare and recently described entity related to cerebral amyloid angiopathy (CAA) and central nervous system vasculitis. The diagnosis in the absence of a biopsy can be made using the clinical-radiological criteria of Chung et al.

Design/Methods

Cases with a possible diagnosis of AAI by MRI were reviewed. A descriptive study of the patients who fulfilled clinical-radiological criteria and iconography is presented.

Results Of the 8 cases with radiological suspicion, 4 met clinical-radiological criteria, of which 3 were AAI and one was primary brain lymphoma. We present a series of three patients, two women and one man, aged between 72 and 85 years. None of them had previous cognitive impairment, 2/3 had subacute cognitive changes, 2/3 focal neurological symptoms, 2/3 headache, 1/3 encephalopathy and 1/3 epileptic seizures. Brain MRI showed leukoencephalopathy with asymmetric confluent or patchy lesions, 2/3 leptomeningeal enhancement, 2/3 superficial siderosis, 2/3 more than 10 microbleeds. In all cases, lobar hemorrhage coexisted with multiple microbleeds. In 2/3 the CSF showed hyperprotein sprain. All patients received megadoses of corticosteroids; 2/3 died, the only survivor being the one who received corticosteroid therapy in the first 24 hours, with a subsequent descending regimen without subsequent immunosuppressive treatment and without relapses.

Conclusions

AAI is a rare entity; In our series, a high mortality was evidenced. The early use of high-dose steroids could be relevant in prognosis and the subject of future studies.

Authors/Disclosures
Alicia Gonzalez-Martinez, MD (Hospital Universitario de La Princesa) PRESENTER	Dr. Gonzalez-Martinez has nothing to disclose.
	No disclosure on file
	No disclosure on file
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	No disclosure on file
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	No disclosure on file
Antonio Barbosa Del Olmo	Antonio Barbosa Del Olmo has nothing to disclose.
	No disclosure on file