Stroke is an incident that leads to disturbance in cerebral function leading to disability and death worldwide. Both acute and chronic kidney disease (CKD) are correlated with an enhanced risk of cerebrovascular events and stroke. The underlying mechanistic approach between stroke and impaired renal function has been explored limitedly, hence, has attracted researchers to explore in depth for developing therapeutic interventions.

Mitochondrial dysfunction following CKD may contribute towards exacerbation of ischemic stroke pathology.