To describe the modifiable risk factor profiles of older adults at high-risk of developing dementia enrolled in a multidomain intervention trial and examine differences by sex and race.

In 2020, 5.8 million people will have Alzheimer’s Disease (AD) and the prevalence is expected to triple by 2050. Modifiable risk factors have shown promise in reducing risk of AD with the potential for broad population health impact, but few studies have examined risk factors by sex and race.

High-risk older adults ≥70 years old with low/normal cognitive performance, English fluency, and at least two modifiable risk factors were recruited to a randomized pilot trial to compare a personalized, pragmatic, multidomain Alzheimer’s risk reduction intervention vs a Health Â鶹´«Ã½Ó³»­ control. Chi squares were used to compare risk factors by sex and race.

SMARRT participants (N=172) had a mean age of 75.5 (SD=4.9), were 64% female, and 78% white. Among non-white participants (n=37), participants identified as Black (41%), Asian (22%), American Indian (16%), Other (16%), and Pacific Islander (5%). The three most prevalent risk factors for both sexes were physical inactivity (males=82%, females=78%), hypertension (males=52%, females=48%), and sleep difficulty (males=47%, females=50%). Similarly, the most prevalent risk factors by race were physical inactivity (white=80%, non-white=81%), hypertension (white=47%, non-white=57%), and sleep difficulty (white=51%, non-white=38%). These differences were not statistically significant by sex or race (p>0.05 for all).