Abstract Details

Title Number and location of cerebral microbleeds (CMBs) are associated with global and domain-specific cognitive impairment

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) Aging and Dementia Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 063

Objective We examined whether the number or location of CMBs are related to cognition.

Background CMBs are associated with risk factors for cognitive dysfunction but their own role is unclear. It is also unclear whether any role is region-specific or a function of global count.

Design/Methods

At the 6th examination of the Multi-Ethnic Study of Atherosclerosis, 256 participants at the Wake Forest field center (Winston-Salem, NC) received 3T brain MRI in addition to detailed cognitive testing (Uniform Data Set v3) and adjudication of cognitive status via expert consensus review. A single trained neuroradiologist graded for large (>1.5 cm) infarcts, CMBs, and lacunes in basal ganglia, cortex, cerebellum, and brainstem. We excluded 4 participants with large infarcts. Linear regression modeled parameter estimates (β (standard error)) per lesion count and global (Montreal Cognitive Assessment, MoCA) and domain-specific cognitive performance (memory, executive, visuospatial, language) as standardized scores adjusted to normative data including age, education, gender, and race.

Results This sample included 252 individuals: mean age (SD) of 72 (7) years, 58% women, 53% African-American, 67% hypertensive, 20% diabetic. Participants were adjudicated to cognitively normal (n=164, 65%), mild cognitive impairment (n=65, 26%), dementia (n=11, 4%), and "other" (n=8, 3%). CMBs were present in 89 (35%) and lacunes in 76 (30%) participants. Total CMBs (β (SE) = -0.08 (0.03), p<0.01), and basal ganglia (β (SE) = -1.10(0.54), p=0.04) and cortex CMB counts (β (SE) = -0.08(0.03), p<0.01), were associated with lower MoCA scores. There were domain-specific associations for memory (total CMB and cortical counts, p’s<0.01) and executive function (basal ganglia and cerebellar counts only, p’s<0.04), but not other domains. Lacunes were not associated with cognitive performance.

Conclusions In this cohort, global and region-specific CMBs were associated with global and domain-specific cognitive impairment while lacunes were not. Our results have important implications for our understanding of vascular biomarkers of cognitive performance.

Authors/Disclosures
Ihtsham Haq, MD, F�鶹��ýӳ�� (University of Miami Miller School of Medicine) PRESENTER	The institution of Dr. Haq has received research support from NINDS. The institution of Dr. Haq has received research support from the Parkinson's Foundation.
	No disclosure on file
Christopher T. Whitlow, MD (Wake Forest School of Medicine)	Dr. Whitlow has nothing to disclose.
Samuel N. Lockhart, PhD (Wake Forest School of Medicine)	The institution of Dr. Lockhart has received research support from NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Timothy M. Hughes	No disclosure on file
	No disclosure on file

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