Abstract Details

Title Early differences in brain MRI segmented temporal gray matter volumes between cerebral arteriolosclerosis, Alzheimer disease, and mixed neuropathologies

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) Aging and Dementia Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 044

Objective We sought to determine brain MRI volumetric differences of segmented temporoparietal structures at mild cognitive impairment and early dementia stages between those with cerebral arteriolosclerosis alone (pARTE), AD alone (pAD), and mixed AD and arteriolosclerosis (ADARTE) neuropathologies.

Background Early cognitive impairment from cerebral small vessel disease and Alzheimer disease (AD) can be difficult to clinically distinguish.

Design/Methods From the National Alzheimer’s Coordinating Center, we defined neuropathology groups of pARTE (n=64), pAD (n=32), and ADARTE (n=49) from a subset of participants who had volumetric analysis of MRI brains obtained within 1 year of clinical evaluation with Clinical Dementia Rating (CDR) score of 0.5 or 1.0, corresponding to mild cognitive impairment or early dementia. We included moderate to severe arteriolosclerosis and/or ABC score for AD of 2-3, after excluding other major neuropathologies. At CDR 0.5 and 1.0, we compared baseline characteristics and volumetry between neuropathology groups using univariate analysis and regression models adjusting for age at MRI, sex, height, cranial volume, vascular risk factors, and apolipoprotein 4.

Results

At CDR 0.5, there were no differences in baseline characteristics apart from diabetes, which was not significant in pairwise comparisons. At CDR 1.0, hyperlipidemia was more prevalent in pAD than in other pathology groups. When comparing volumetry at CDR 0.5, we found that pAD had smaller right superior temporal gray matter volumes than pARTE (12.4 vs 13.7 cc, p=0.033). At CDR 1.0, ADARTE featured multiple temporal gray matter segments with smaller volumes than pARTE, but no differences from pAD. In fully adjusted multivariate models, these differences remained significant.

Conclusions We find more differences in brain MRI segmented volumes at early dementia than mild cognitive impairment, most apparent between pARTE and ADARTE groups. This may suggest an early cumulative effect of AD and cerebral small vessel disease in temporal lobe atrophy that is distinguishable with volumetric analysis.

Authors/Disclosures
Dixon Yang, MD (Rush University Medical Center) PRESENTER	Dr. Yang has nothing to disclose.
Arjun V. Masurkar, MD (NYU Langone Medical Center)	The institution of Dr. Masurkar has received research support from NIH. The institution of Dr. Masurkar has received research support from Alzheimer's Association. The institution of Dr. Masurkar has received research support from BrightFocus Foundation. Dr. Masurkar has received personal compensation in the range of $500-$4,999 for serving as a IRGP Advisory Council Member with Alzheimer's Association. Dr. Masurkar has a non-compensated relationship as a Steering Committee Member with Alzheimer's Disease Cooperative Study that is relevant to �鶹��ýӳ�� interests or activities.

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