To observe how stroke outcome differs with the method of treatment.

This prospective observational study enrolled 106 participants who underwent thrombolysis (n=47) , thromboaspiration (n=10) and DAPT (n=49) presenting with acute ischemic stroke within 6 hours of symptoms.  Study was commenced after obtaining clearance from IEC & written informed consent among patients who fulfilled inclusion & exclusion criteria. Data was collected in case record forms and included history, physical examination, imaging findings, NIHSS (baseline, 1 hour, 24 hours and 7 days) and modified rankin scale (mRS) at 1&3 months and were analysed using R™. Normality of distribution the tests of significance were tested and processed using spss 22version.

Thromboaspiration was observed to have  lower age (p=0.003), higher proportion of smokers (p=0.04), aphasia (p=0.02),  dyslipidemia (p=0.004) and higher NIHSS (p=0.01) at baseline.Participants who underwent thrombolysis had significantly lower NIHSS at 1 hour (p<0.001), 24 hours (p=0.01) and at 7 days (p=0.005). Significantly higher reduction in NIHSS was observed with thromboaspiration (p=0.02) compared to other groups. Significantly lower mRS at 3 months was observed for all treatment groups including both rt-PA and higher reduction in mRS was observed with thrombolysis (p=0.03). Between alteplase and tenecteplase, no significant difference in reduction in NIHSS and mRS was observed. 8.8% (n=5) participants had symptomatic intracranial hemorrhage (sICH). 10% (n=1) and 8.5% (n=4) in participants who underwent thromboaspiration and thrombolysis respectively had sICH. 10.7% (n=3) and 5.3% (n=1) participants who received alteplase and tenecteplase had sICH.