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Abstract Details

Characterization of the retina of the triple-transgenic mice model of Alzheimer's disease: onset and progression of the disease
Aging, Dementia, and Behavioral Neurology
P9 - Poster Session 9 (12:00 PM-1:00 PM)
10-005
In this work, we aim to characterize and monitor the differences between the retina of the triple-transgenic mice model of Alzheimer's disease (3xTg-AD) and controls (wild-type - WT) at the ages of one, two, and three months using texture analysis and thickness measurements of OCT data.
The use of mouse models offers the opportunity of collecting information through the progression of AD since the age of one month, intending to identify biomarkers for the onset and progression of the disease. We explore the use of texture analysis, in addition to thickness measures, to characterize the neuro-retina.

One hundred retinas of 100 mice (50 3xTg-AD/50 WT) were imaged by OCT (Phoenix Micron IV OCT) to produce 512 B-scans of 512 A-scans each. OCT B-scans were segmented to calculate retina’s thickness and texture metrics of computed fundus images.

Segmentation was achieved developing a convolution neural network based on previously segmented B-scans. All processing, software development and statistical analyses were performed using Matlab R2019a.

Over 73% of the texture metrics presented statistically significant differences between groups at the level of p ≤ 0.001, in all neuro-retina layers (RNFL to ONL), and at all time-points. The top layers (RNFL to IPL) show a steady difference between groups with 142/261, 124/282, and 138/244 texture metrics, respectively at 1, 2, and 3 months-old, while bottom layers (INL to ONL) show 119/261, 158/282, and 106/244 texture metrics differences.

The neuro-retina of the 3xTg-AD mice group is thinner compared to the WT group (p ≤ 0.05) with average differences ranging from 12.97 to 4.20 microns, respectively at the ages of one and three months.
These results demonstrate that transgenic mice present marked differences to the WT group since the age of one-month-old. Henceforth, this model may be too extreme to establish onset biomarkers of AD to human studies.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file