Abstract Details

Title Neurological Comorbidities in Hospitalized Patients with Opioid Abuse

Topic General Neurology

Presentation(s) P8 - Poster Session 8 (8:00 AM-9:00 AM)

Poster/Presentation
Number 6-009

Objective Determine the prevalence, nature, and the burden of neurological comorbidities in hospitalized patients with opioid abuse.

Background Although ravages born of the nationwide opioid epidemic crisis are well chronicled, little is known about neurological comorbidities associated with opioid abuse.

Design/Methods We analyzed University of Kentucky Healthcare Enterprise discharge data for 34,414 subjects during October 1, 2016–September 30, 2017. Patients with opioid abuse were identified by using ICD-10: F11. – Mental and behavioral disorders due to use of opioids. Of 2,183 opioid abuse subjects identified, 360 were selected for chart review matched for age, gender, race, and urban-rural residence. Four neurologists reviewed the medical records; 90 records were randomly assigned to each investigator, and no statistically significant inter-rater disagreement identified. Thirteen subjects had no documentation of opioid abuse, leaving 347 subjects for analysis.

Results Among discharged patients, opioid abuse prevalence was 6.3% and significantly more prevalent among younger patients (Mean: 40; SD: 12.8; p<0.0001), women (55.4%; p<0.0001), Caucasians (95.3%; p<0.0001), and urban population (29.1%; p 0.0277). Of 347 subjects with opioids abuse reviewed, 179 (51.6%) had neurological comorbidities. This group included encephalopathy (130; 72.63%), neuromuscular disorders (42; 23.46%), seizure disorders (23; 12.85%), spine disorders (23; 12.85%), strokes (20; 11.17%), central nervous system infections (3; 1.67%), and movement disorders (2; 1.12%). No posterior reversible encephalopathy syndrome, leukoencephalopathy, or transverse myelitis identified. Neurological comorbidity contributed to the admission decision in 162 subjects (46.69%).

Conclusions Neurological comorbidities are a common and heretofore underappreciated contributor to the disease burden of those with opioid abuse. Comorbidities traditionally ascribed to opioid abuse were not found in this study. The importance of neurological comorbidities should be considered in the clinical as well as public health discussions surrounding opioid epidemic crisis.

Authors/Disclosures
Kevin R. Nelson, MD, F�鶹��ýӳ�� (University of Kentucky) PRESENTER	No disclosure on file
Katelyn Dolbec, MBBS (University of Kentucky College of Medicine)	No disclosure on file
William D. Watson, MD, F�鶹��ýӳ�� (NPG Brain & Concussion)	No disclosure on file
	No disclosure on file
Mam Ibraheem, MD	Dr. Ibraheem has nothing to disclose.

�鶹��ýӳ��

�鶹��ýӳ��