Consecutive patients of thrombolysed ischemic stroke in a single centre were studied; demographic data, safety variables (death and symptomatic intracerebral haemorrhage(sICH) as per European Cooperative Acute Stroke Study II(ECASS II) criteria) and out come at 90 days {excellent (modified Rankin Scale-mRS 0-1) and functional independence(mRS 0-2)}  were analysed. Statistical analysis was performed with Medcalc software.

106 patients were studied, 56 receiving Actilyse and 50 Tenectase. The mean age was 67 and 59 years respectively(p=.001) with similar sex distribution(p=.258). Mean Baseline national Institute of Neurological Disorders and Stroke(NIHSS) score was similar {12.5 and 10.63(p=.077)} in both arms. Mean door to needle time was 132 and 123 minutes respectively. Hypertension was  more in the actilyse group(82%vs 54%, p=.004); Diabetes Mellitus was seen in similar proportions(53% and 44%, p=.43) in both the groups  but significantly more prevalent than in SITS NEW patients(p=004). Hypertension was more prevalent in the actilyse group(p=.001).

sICH was seen in 2,0 and 33 patients respectively in the actilyse, tenectase and SITS NEW groups with no statistical difference between actilyse and SITS NEW groups. There were 3(2related), 1(0) and 59(12) deaths in these groups. Excellent outcome was seen in 75%, 58% and 43% in these groups. Functional Independence was significantly better in actilyse and tenectase groups compared to SITS NEW(p=.035, .005)