The guideline working group consisted of eleven Canadian ALS clinicians with geographic representation from across the country.  Clinical questions of interest were obtained by surveying clinicians and staff at all the Canadian ALS clinics, and then further refined by the working group.  Literature searches on the questions were conducted by a consulting firm (Centre for Effective Practice) with guideline development experience.   Medline, EMBASE, and CINHAL databases were searched.  Retrieved abstracts were screened for inclusion criteria, and selected publications were reviewed for relevance and data quality.  Guideline statements for each clinical question were developed on an iterative basis until consensus was obtained.  Finally, each guideline statement was assigned an evidence rating, which included the option of expert consensus.  Public feedback on the draft recommendations was elicited. 

Canadian ALS Best practice recommendations have been developed covering the topics of: 1) delivery of an ALS diagnosis, 2) disease related treatment, 3) multidisciplinary care, 4) respiratory management, 5) nutrition management, 6) DVT risk, 7) medication alignment, 8) symptom management, 9) dysarthria management, 10) exercise in ALS, 11) cognition, 12) caregiver burden and support, 13) palliative care, and 14) medical assistance in dying.