Abstract Details

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Abstract Details

Title Characteristics of wake-up stroke through the timing – An experience from a north African cohort

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P7 - Poster Session 7 (5:30 PM-6:30 PM)

Poster/Presentation
Number 4-021

Objective

Our objective is to identify the characteristics WUS among a north African population.

Background

Wake-up Stroke (WUS) doesn’t have distinctive clinical characteristics. Physiological changes in circadian rhythm (cerebral autoregulation, vascular tone, blood pressure, coagulation profile) are thought to predispose to WUS.

Design/Methods

Prospectively assessed consecutive patients admitted (within 3 days of symptoms) to neurology department of Habib Bourguiba Hospital of Sfax (Tunisia) (during 4 months). Patient’s demographics, risk factors, stroke location, etiology (TOAST criteria), functionalstatus (NIHSS, FIM score) and mortality rate within the first thirty days after stroke onset were assessed. WUS was grouped, into Group A (0:00–06:00), B (06:01–12:00), C (12:01–18:00) and D (18:01–23:59) based on the ‘wake up’ time. Statistical analysis was done using SPSS version 20.

Results Of the 200 patients fulfilling inclusion criteria-159 were ischemic stroke. From them 66 (33%) were WUS having more female (41,1% vs 38,8%; p-0.86), less AF (28,6% vs 33%; p-0.59), less hypertension (58,9% vs 63,1%; p-0.61) and more insular stroke (35,7% vs 18,4%; p-0.021). WUS Group A (n = 27) had higher NIHSS (10), more FA (40.7%) and insular stroke (33, 3%).WUS Group B (n = 74) had more male (64,9%), right sided stroke (64,8%), vertebrobasilar stroke (21,6%) and high mortality rate (21,6%). WUS Group C (n = 33) had older age (70,67 years old), more female (45,5%) and higher FIM score (70). WUS Group D (n = 25) had more hypertension (64%) and left sided stroke (54,5%).

Conclusions

The clinical characteristics of our north African WUS were not significantly different from non-WUS and between WUS Groups according to the ‘wake up’ time. However, this study revealed a significantly higher rate of involvement of insular cortex in WUS, the rationale behind this occurrence is yet to be unraveled.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Chokri A. Mhiri, MD (Habib Bourguiba Hospital)	Prof. Mhiri has received personal compensation for serving as an employee of Hikma. Prof. Mhiri has received personal compensation for serving as an employee of Sanofi Genzyme. Prof. Mhiri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Prof. Mhiri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche.