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Abstract Details

Progression to Secondary Progressive Multiple Sclerosis and its Early Risk Factors: A Population-based Study
Multiple Sclerosis
P5 - Poster Session 5 (8:00 AM-9:00 AM)
9-013
Apprized the proportion of relapsing-remitting multiple sclerosis (RRMS) patients (RRMS) who converted to secondary progressive MS (SPMS) and survived its influential factors.
Secondary progressive course causes severe and irreversible neurological impairments and there is limited therapeutic option with unidentified efficacy. Also, determine the onset of SP course, especially in patients with prior history of relapsing-remitting phase, is challenging. Despite increased studies to assess the time of conversion and its risk factors, this specific area still remains unclear.
This prospective study was conducted within a 7-years from 2012 to 2019. Information of MS patients at diagnosis date were extracted from a prospective population database. Demographic features included sex, age, education, birth of season, and handedness were extracted from database. Age, initial manifestation, MRI findings, and Expanded Disability Status Scale (EDSS) score were assessed. A Kaplan-Meier curve was used to report the proportion of patients with progression to progressive MS. Cox proportional hazards model was used to find the association between the various factors and progression to progressive MS.
Out of 1903 patients with RRMS at baseline, 293 (15.4%) patients progressed to SPMS during follow up. The incidence rate of progressive MS was 17.8% during the entire study period. The 50% risk for convert from RRMS to SPMS was 20 years. On the multivariate cox regression analysis positive history of smoking, higher age, higher EDSS, motor and brainstem dysfunction, and lesion in spine at the diagnosis are the significant prognostic factors of switch from RRMS to SPMS.
Rate of conversion to SPMS reduced compared to previous natural studies. The identified prognostic factors should be considered in the treatment of patients.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file