Abstract Details

Title Central Cognitive Processing Speed Is an Early Marker of Huntington's Disease Onset

Topic Movement Disorders

Presentation(s) P5 - Poster Session 5 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-002

Objective

To utilize the Computerized Test of Information Processing (CTiP) to examine central processing speed as an early marker of Huntington’s disease (HD) onset.

Background The CTiP, administered on a laptop, is a relatively simple and useful tool for evaluating the extent to which neurological conditions affect cognitive processing speed. It consists of three computerized reaction time (RT) subtests that progressively increase in task complexity -- Simple RT (SRT); Choice RT (CRT), with an added decisional component; and Semantic Search RT (SSRT), with an added conceptual component.

Design/Methods Gene carriers (n=102) were categorized using the UHDRS Total Functional Capacity and Penny Burden of Pathology score as early pre-manifest (n=33), transitional (i.e. individuals close to disease onset or with very mild HD; n=23), or mild-moderate HD (n=46). Subjects were administered the CTiP in addition to traditional cognitive assessments (MoCA, MMSE, Verbal Fluency, Symbol Digit, Trail Making Test) commonly used in HD. Central processing speed was measured using motor-corrected CRT and SSRT values. A one-way ANCOVA adjusting for age was used to compare group performance on the RT subtests.

Results The mild-moderate HD subjects showed significantly slower reaction times in all conditions (p<0.001) as compared to NC. Importantly, even transitional subjects showed significantly slower reaction times on the SSRT (p<0.01), and in central cognitive processing on both motor-corrected subtests (p<).05, compared to NC. Furthermore, in the transitional subjects, the CTiP subtests showed effect sizes comparable to, or higher than, those for cognitive assessments commonly used in HD, even when motor speed was taken into account.

Conclusions

Our results suggest that the CTiP may be a useful and early marker of deficits in central cognitive processing in individuals with, and transitioning to, HD.

Authors/Disclosures
Jody Corey-Bloom, MD, PhD, F�鶹��ýӳ�� (UCSD Neurosciences) PRESENTER	Dr. Corey-Bloom has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for UniQure. Dr. Corey-Bloom has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Teva Pharmaceuticaks. Dr. Corey-Bloom has received personal compensation in the range of $10,000-$49,999 for serving as a Co-Director, HD-Net with Huntington Study Group.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Brenton A. Wright, MD	Dr. Wright has nothing to disclose.
Paul Gilbert, PhD (SDSU-UCSD)	Dr. Gilbert has nothing to disclose.

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