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Abstract Details

The Association Between the SUDEP Biomarker and Obstructive Sleep Apnea in an Unselected patients with Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
P5 - Poster Session 5 (8:00 AM-9:00 AM)
12-002

We sought to investigate the relationship between the SUDEP-7 inventory, sudden unexpected death in epilepsy (SUDEP) biomarker and apnea-hypopnea index (AHI).

SUDEP is a major cause of death in patients with epilepsy. Terminal apnea superseded asystole, and 88% of SUDEP cases occurred during sleep, suggesting potential roles for either a sleep state dependent influence upon SUDEP risk, and/or contributions of sleep disorders such as sleep apnea to SUDEP pathophysiology.

We conducted a cross-sectional study of consecutive subjects more than 15-year-old without known sleep disorders or prior PSG were recruited from a single epilepsy clinic in a tertiary care facility. Participants underwent polysomnography. Scoring was performed by a blinded board-certified sleep physician and senior sleep technologist.

Our study population consisted of 97 participants. Median AHI of our populations was 2.4 (range = 0 – 82.4). 16 (16.4%) patients with epilepsy were found OSA (AHI > 15), 12 patients have mild to moderate OSA and 4 patients have severe OSA. Median SUDEP-7 inventory score was 1 (range = 0 - 7). There were no significant differences in total SUDEP-7 inventory score and AHI or non-REM AHI or REM AHI or supine AHI or non-supine AHI. Also, SUDEP-7 inventory score > 4 did not showed association with AHI or non-REM AHI or REM AHI or supine AHI or non-supine AHI.

Our study did not found association between OSA and SUDEP biomarker in an unselected patients with unknown cause epilepsy
Authors/Disclosures

PRESENTER 		No disclosure on file
Kanitpong Phabphal No disclosure on file
Pasiri Sithinamsuwan, MD (Phramongkutklao Hospital) No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file