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Abstract Details

Anxiety symptoms in youth with and without tic disorders
Child Neurology and Developmental Neurology
P5 - Poster Session 5 (8:00 AM-9:00 AM)
5-007
To evaluate and compare anxiety in youth with and without tic disorders.
Chronic tic disorders (CTDs) affect 1-3% of youth; approximately half of these individuals have anxiety. It is not known if anxiety symptoms in CTDs are the same as anxiety symptoms in the general population. Understanding the anxiety phenotype in CTDs can inform future treatment trials.  
This is a secondary analysis of data from a cross-sectional study of the impact of tic disorders. Caregiver-child dyads were enrolled for a single study visit. Anxiety symptom severity was measured using the self-reported Multidimensional Anxiety Scale for Children (MASC). We compared MASC scores in youth with tic disorders and community controls. We also compared MASC scores in our tic sample to archival data of baseline MASC scores from the Child/Adolescent Anxiety Multimodal Study (CAMS), the largest randomized controlled intervention trial in childhood anxiety. CAMS data were used to represent anxiety disorders in the general pediatric population. 
The MASC was completed by 176 youth with tic disorders, 93 controls, and 488 CAMS participants. Ages were comparable in each group. There was a higher proportion of males in the tic group compared to the other groups. MASC total scores were higher in the tic group (mean 53.0, SD 11.2) than the controls (mean 45.4, SD 10.2; p<0.0001). MASC total scores were similar in the tic (median 52.0, IQR 44.0-60.8) and CAMS (median 51.0, IQR 42.0-60.0; p=0.13) groups. Separation anxiety severity was higher in the tic (median 59.0, IQR 51.3-70.0) than in the CAMS (median 49.0, IQR 43.0-55.5; p<0.0001) groups.

Anxiety symptom severity was higher in youth with tic disorders compared to community controls and similar to that of CAMS participants. Separation anxiety severity was higher in the tic group than in CAMS participants. This may have implications for targeting anxiety treatment in tic disorders. 
Authors/Disclosures
Jennifer A. Vermilion, MD (University of Rochester)
PRESENTER 		The institution of Dr. Vermilion has received research support from Centers for Disease Control. The institution of Dr. Vermilion has received research support from Emalex Biosciences. The institution of Dr. Vermilion has received research support from Biomarin. The institution of Dr. Vermilion has received research support from Neurogene, Inc. Dr. Vermilion has received personal compensation in the range of $500-$4,999 for serving as a Invited Speaker with Tourette Association of America. Dr. Vermilion has received personal compensation in the range of $500-$4,999 for serving as a Invited Speaker with Centers for Disease Control and Prevention and American Academy of Pediatrics.
No disclosure on file
Erika F. Augustine, MD, FÂ鶹´«Ã½Ó³»­ (Kennedy Krieger Institute) The institution of Dr. Augustine has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Latus Bio. Dr. Augustine has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for American Board of Psychiatry and Neurology. Dr. Augustine has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Annals of Neurology. The institution of Dr. Augustine has received research support from NIH. The institution of Dr. Augustine has received research support from Beyond Batten Disease Foundation. Dr. Augustine has received publishing royalties from a publication relating to health care. Dr. Augustine has a non-compensated relationship as a Member, Board of Directors with American Brain Foundation that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Augustine has a non-compensated relationship as a Scientific Advisor with ARIA that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.
Heather Adams The institution of Heather Adams has received research support from Current: NIH; Past: Abeona; Batten Research Alliance; American University Centers on Disabilities. An immediate family member of Heather Adams has received publishing royalties from a publication relating to health care. Heather Adams has received personal compensation in the range of $500-$4,999 for serving as a Consultant with Critical Path Institute.
Amy Vierhile, NP, DNP (University of Rochester Medical Center) Ms. Vierhile has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Greenwich Biosciences.
No disclosure on file
No disclosure on file
Michael McDermott No disclosure on file
No disclosure on file
Roger M. Kurlan, MD, FÂ鶹´«Ã½Ó³»­ No disclosure on file
No disclosure on file
No disclosure on file
Jonathan W. Mink, MD, PhD, FÂ鶹´«Ã½Ó³»­ The institution of Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amicus. The institution of Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurogene. Dr. Mink has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for TEVA. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for PTC Therapeutics. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Applied Therapeutics. Dr. Mink has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Â鶹´«Ã½Ó³»­. The institution of Dr. Mink has received research support from Neurogene. The institution of Dr. Mink has received research support from NIH. Dr. Mink has received publishing royalties from a publication relating to health care. Dr. Mink has received personal compensation in the range of $500-$4,999 for serving as a Member, Study Section with NINDS.