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Abstract Details

Patient and Treatment Characteristics of a Large US Sample of Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Initiating Intravenous Immunoglobulin (IVIG) Therapy
Autoimmune Neurology
P5 - Poster Session 5 (8:00 AM-9:00 AM)
15-005
Identify and describe demographic and clinical characteristics of patients with CIDP in the US initiating IVIG treatment. 
CIDP is a rare immune-mediated neuropathy with significant burdens. Per guidelines, IVIG is first-line therapy for CIDP. The clinical profile of patients with CIDP newly initiating IVIG is not well characterized. 
This claims-based cohort study identified adult immunoglobulin-naïve patients with CIDP from 2008–2018 via diagnosis coding using the IBM® Watson HealthTM MarketScan® Research Databases. Clinical and demographic characteristics of new IVIG users were described overall and by initial IVIG product. Probability of receiving available IVIG treatments based on baseline characteristics was evaluated by logistic regression and propensity score methods.
Demographics (eg, age, sex, region) were similar between new IVIG users (n = 3975) and the full cohort (n = 32 090). However, new IVIG users, compared with the full cohort, tended to have greater  comorbidity and symptom burden, which included weakness and/or difficulty walking (61% vs 35%), neuropathic pain (80% vs 64%), diabetes (33% vs 29%), hypertension (62% vs 52%), leukemia/lymphoma (5% vs 3%), hypothyroidism (21% vs 18%), rheumatoid arthritis (19% vs 14%), other autoimmunity disorders (7% vs 3%), and others, respectively. Median age of new IVIG users was 58 years, and 59% were male. Most (88%) received outpatient treatment, and 41% had prior CIDP treatments other than immunoglobulin (35% high-dose corticosteroids). Ancillary testing consisted of: electrodiagnostic testing (63%), cerebrospinal fluid analysis (45%), imaging studies (36%), and nerve biopsy (21%). Clinical and demographic characteristics tended to be similar among patients by initial IVIG product, except for calendar year of index treatment.
There was a trend to initiate IVIG in patients with CIDP who had greater comorbidity and symptom burden. No correlation was observed between patient characteristics and selection of initial IVIG treatment; rather, differences in selection varied by year.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Ihor Sehinovych (Takeda) No disclosure on file
Shailesh Chavan Shailesh Chavan has received personal compensation for serving as an employee of Takeda Pharmaceuticals. Shailesh Chavan has received stock or an ownership interest from Takeda Pharmaceuticals.
Nizar Souayah, MD, FÂ鶹´«Ã½Ó³»­ (NJMS) Dr. Souayah has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Takeda. Dr. Souayah has received publishing royalties from a publication relating to health care.