Hypoglycorrhachia is a low glucose level in the Cerebrospinal Fluid (CSF). It may be associated with a differential diagnosis including infection, inflammatory conditions, strokes, malignancy, and leptomeningeal carcinomatosis. The pathophysiology of hypoglycorrhachia may be related to glucose transport and glucose metabolism within the cerebrum. The physiological role of glucose within the CSF and the contribution of hypoglycorrhachia to clinical pathology has yet to be firmly established. To date, while there have been multiple case reports of hypoglycorrhachia in leptomeningeal carcinomatosis including from lung primaries, none so far have detailed persistently completely undetectable CSF glucose levels, known as aglycorrhachia.

This case illustrates the possibility of undetectable CSF glucose, or aglycorrhachia, in the setting of leptomeningeal carcinomatosis.