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Abstract Details

Late Onset Multiple Sclerosis: an Epidemiologic Study from the First Brazilian MS Center
Multiple Sclerosis
P4 - Poster Session 4 (5:30 PM-6:30 PM)
9-014
 To describe the demographic and clinical characteristics in patients with late onset multiple sclerosis currently in treatment in the first Brazilian center for multiple slerosis, founded in 1997.
Late onset multiple sclerosis (LOMS) is characterized by the onset of symptoms after 50 years of age, representing 4.5% of patients with multiple sclerosis (MS).
In this retrospective study, clinical and demographic data of 399 patients with definite MS using the revised 2017 McDonald diagnostic criteria were reviewed between October 2018 and September 2019 from the medical records of a MS Care and Treatment Center in Sao Paulo, Brazil. Clinical data included: age at onset; first-reported symptoms; disease course and duration; EDSS scores in the first and last visit.
LOMS frequency was 3.5%, mean age at the time of diagnosis was 52.78 years and none of patients experienced an onset after age 60. Most patients were female (71.42%) and had a relapsing-remitting disease course (71.42%). Motor onset symptoms were more prevalent (42.85%), followed by optic neuropathy (21.42%). The mean EDSS score at the first and last visit was 4 and 4.35, respectively. Median time to EDSS 6 was 1.5 years.
LOMS diagnosis is not common and it is usually delayed. Despite the higher prevalence of relapsing-remitting course in our sample, when the diagnosis is made the patients have a high disability score, in addition to a higher prevalence of motor disability.
Authors/Disclosures
Keila Narimatsu, MD (Gynari)
PRESENTER 		No disclosure on file
No disclosure on file
Natalia T. Mendes, MD (Santa Casa de Misericórdia de São Paulo) Dr. Mendes has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Guilherme Olival No disclosure on file