Abstract Details

Title Epilepsy and multiple sclerosis: a comorbidity in Argentinian cohort patients without progressive forms

Topic Multiple Sclerosis

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 9-016

Objective 1) To analyze demographic /clinical characteristics of Multiple Sclerosis(MS) patients who presented Epilepsy(E) during the course of the MS 2) to describe type of seizures 3) to establish the risk of epilepsy after a single seizure and/or status epilepticus

Background The relationship between severity of MS and the risk of epilepsy E have been reported in recent studies with an incidence of 2.28%, prevalence 3.09% higher than general population (< 1%). Although in some cases, a seizure may be the only manifestation of a MS relapse, patients with progressive forms of MS would be at a risk of epilepsy after a single seizure. The risk of E in MS would be considered at time to decide whether to add other chronic therapy to MS treatment

Design/Methods We included 2418 records of MS patients with a F-U between years 2000-2018. Seizure /status epilepticus were defined as the International League Against Epilepsy

Results We found 7 MS with single seizure; 28 patients with MS and E : 1) MS characteristics: Gender n(%): Male 12(42,8); Female 16(57,2); age at onset (y): 29,8±13,97; age at diagnostic (y): 33,29±13,25; clinical presentation(n%) : Relapsing Remiting MS 21(75); Secondary Progressive MS 5(17.8); Primary Progressive MS 2(7.2); basal EDSS 2,67±1,47; final EDSS 4,27±2,48. 2) time to E after MS diagnosis was 3876 days±2419(SD) 3) seizures n (%): generalized onset 18 (64.3), focal onset with awared 5(17.8) and impared awared 1(3.57), focal to bilateral tonic clonic 1(3.57), unknown 3(10.7). 89% of patients received 1 anti-epileptic drug (AED).Refractory seizure was not reported

Conclusions Although E is a common comorbidity in MS, we found a risk for E of 0.011% in 10 y of F-U. However, there was not a clear relationship with progressive phenotypes. Patients with MS and E developed more disability after E diagnosis

Authors/Disclosures
Guido D. Vazquez II, PhD (Neurociencias Favaloro) PRESENTER	Dr. Vazquez has nothing to disclose.
Judith D. Steinberg, MD (Hospital Britanico)	No disclosure on file
	No disclosure on file
	No disclosure on file
Anibal Chertcoff (University of British Columbia)	Anibal Chertcoff has nothing to disclose.
Vladimiro Sinay, MD	No disclosure on file
Adriana Carra	No disclosure on file

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Abstract Details