Abstract Details

Title Low serum Uric Acid levels are related to dyskinesia and postural instability/gait difficulty in Parkinson's Disease

Topic Movement Disorders

Presentation(s) P4 - Poster Session 4 (5:30 PM-6:30 PM)

Poster/Presentation
Number 3-008

Objective We conducted a cross-sectional study to evaluate the associations among serum Uric Acid (UA) levels, dyskinesia and motor subtypes in PD patients.

Background UA is a natural antioxidant with a potential neuroprotective effect on Parkinson's disease. Besides, it has been hypothesized that the UA levels decrease with worsening in progression of the disease.

Design/Methods Serum UA levels were measured in 113 participants (n=75 PD and n=38 healthy controls - HC). The Unified PD Rating Scale (MDS-UPDRS) III and Hoehn and Yahr were used to assess the severity of disease. Motor subtypes were determined in 3 categories: Dominant Tremor (DT), postural instability/gait difficulty (PIGD) and mixed. Dyskinesia was assessed by 4.1 subitem of UPDRS-VI. To compare men and women U-Mann Whitney test was performed. Spearman’s correlation was used to relate UA and dyskinesia. A general linear model was adjusted for sex and motor subtypes to evaluate UA differences. Bonferroni post-hoc was executed for multiple comparisons.

Results MDS-UPDRS score was 45.15±1.86 and MDS-UPDRS-III was 86.15±3.62. Serum UA levels were significantly lower in PD women than HC women (U= 817.000; p= 0.014) and men PD (U= 170.000; p= 0.038). Same effect is observed in PD women (U= 371.000; p<0.001) when compared PD men. An inverse correlation between UA and Dyskinesia has been found only in women (r= -0.333; p= 0.044), as well as functional impact of dyskinesias in women (r= -0.496; p= 0.002). Serum UA levels did not differ between the three motor subtypes (F= 0.601; p= 0.551), however, were different in sex (F= 10.183; p= 0.002) according motor subtype. The effect of sex was observed only in PIGD patients (p= 0.003).

Conclusions We found a difference in serum UA related with sex in PIGD motor subtype, associated with a decreasing in women PD. These results suggest UA could be an important biomarker for motor aspects in PD.

Authors/Disclosures
PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
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Abstract Details