Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Patient and Caregiver Preference for Route of Administration of a Benzodiazepine for Control of Increased Seizure Activity in Stable Patients
Epilepsy/Clinical Neurophysiology (EEG)
P4 - Poster Session 4 (5:30 PM-6:30 PM)
12-005
To determine preferences for oral dissolving film strip versus nasal spray for seizure rescue treatment in a real-world population of patients with epilepsy and their caregivers.
Patients with epilepsy on stable treatment regimens requiring intermittent use of a benzodiazepine for seizure rescue may soon have access to diazepam or other benzodiazepines delivered through oral film or nasal spray. Little is known regarding patient/caregiver preference for routes of administration other than currently approved diazepam rectal gel.
Patients with epilepsy or their caregivers who used diazepam intermittently to control increased seizure activity participated in an online survey. All participants were prescreened to ensure they met survey qualifications. Respondents were asked to identify a preference for route of administration, initially without administration instructions, and then again after reviewing instructions for administration of each product.
Of 60 respondents surveyed (29 patients; 31 caregivers), 35 (58%) reported ≥5 breakthrough seizures in the past 12 months, and 33 (55%) had used diazepam to control episodes of seizure activity. The majority (41/60 [68%] preferred an oral film strip formulation to a nasal spray formulation both prior to and after being provided administration instructions for each product. When selecting a rescue seizure medication, the 3 most important factors identified by the overall cohort were effectiveness, immediacy, and tolerability. Minimal administration site irritation and ability to store the product at most temperatures were the most important tolerability and portability considerations overall, respectively. Ability to carry the product in a small wallet/purse was the most important portability consideration for patients. The ideal amount of time to access, prepare, and administer the medication is ≤5 minutes (92% of respondents).
Most patients and caregivers chose an oral dissolving film over a nasal spray as their preferred route of administration for a benzodiazepine to control increased seizure activity.
Authors/Disclosures
Gary Slatko, MD (Aquestive Therapeutics)
PRESENTER 		Dr. Slatko has received personal compensation for serving as an employee of Aquestive Therapeutics. Dr. Slatko has received personal compensation in the range of $100,000-$499,999 for serving as a Consultant for Aquestive Therapeutics.
Ayanna Santos, PHARM D No disclosure on file