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Abstract Details

EEG Patterns Predicting Poor Prognosis In Elderly Patients With Generalised Convulsive And Non-Convulsive Status Epilepticus
Epilepsy/Clinical Neurophysiology (EEG)
P4 - Poster Session 4 (5:30 PM-6:30 PM)
12-001

To investigate prognostic value of  periodic epileptiform discharges in elderly patients with generalised convulsive and non-convulsive status epilepticus(NCSE).
Prognostic implications of periodic epileptiform discharges in EEG in elderly patients with status epilepticus still remains unclear

A total of 93 patients were recruited randomly for the study with age >60 years (mean: 67.1 ±7.0 years, M: F= 2.3:1) from Aug’ 2015 to Dec’ 2016. Patients underwent EEG at admission and outcome was measured using a modified Rankin scale (mRs) for neurological disability (0-6) at 1 month followup.

EEG data at admission was available for 93 patients. Total 15/78 (5.2%) patients succumbed to status epilepticus. All 15/15 (100%) patients had abnormal EEG [background slowing=5, interictal discharges=2, Lateralised Periodic Discharges (LPDs)=3, Generalised Periodic Discharges (PDs)=2, Ictal rhythm=3). Total 63/78(80%) patients who were alive had abnormal EEG (interictal discharges=24, background slowing to theta to delta range=16, beta fast activity=16, LPDs=3, PDs=2, Ictal rhythm=2). Three types of NCSE patterns were noted 1) LPDs (5/10), 2) PDs (3/10), 3) Ictal rhythm (2/10). EEG abnormalities were not significantly different between SVA and LVM groups (p=0.51). Linear regression analysis indicated that type of abnormality in EEG alone explained 18% of the variance (R2=0.18,F=6.61, p<0.05). Patients with LPDs (β=1.73,p=0.02), PDs (β =2.4, p=0.01) and ictal rhythm(β=2.7,p=0.001) significantly predicted mRs scores at 1 month without any significant difference between the two treatment groups (p=0.959)

LPDs, PDs or ictal rhythm could significantly predict morbidity at 1 month in elderly patients with status epilepticus irrespective of the type of antiepileptic drug administered.

Authors/Disclosures
Devavrat H. Nene, MBBS, DM
PRESENTER 		No disclosure on file
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Sanjib Sinha, MD (Dept of Neuro/NIMHANS) No disclosure on file