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Abstract Details

Electromyographic Assessment of Motor Fatigue in Acute and Early Sub-Acture Stroke Patients: A Preliminary Study
Neuromuscular and Clinical Neurophysiology (EMG)
P2 - Poster Session 2 (8:00 AM-9:00 AM)
1-006

To characterize motor fatigue in the acute and early subacute stages after stroke, and to develop a protocol using a computerized exercise training system to measure motor fatigue in the inpatient setting.
Motor fatigue has been described as a feature of abnormal motor control that can occur after injury to the central nervous system, contributing to post-stroke disability. The pathophysiology underlying motor fatigue is unclear. Prior studies focused on patients in the chronic stage after stroke, and little is known about motor fatigue in the early post-stroke period. By testing patients in the acute and early subacute stage post-stroke, we minimize the contribution of muscle atrophy/muscle fatigue and can focus on fatigue attributable to the recent injury to the motor system. 
Subjects: Patients enrolled from the inpatient stroke service with weakness of one arm and no prior arm weakness. Study Design: Surface Electromyography (sEMG) signals are measured during repetitive sets of wrist flexion and extension.  A computer real-time biofeedback system is used to motivate patients. Properties of the sEMG recordings including relative amplitude, delay, and motor unit firing rates are analyzed and the results of the weak side compared with the healthy side. 
Preliminary results show serial decrease in sEMG amplitude and firing rate of EMG signals in the paretic arm as compared to the unaffected arm. Ongoing data collection will further characterize how the sEMG signals change over the first few weeks post-stroke, and compare findings with prior studies on motor fatigue in chronic stroke patients.

Motor fatigue has been studied in chronic stroke patients but little is known about how it evolves early after stroke. Further recognition and studies on motor fatigue may help facilitate development of better rehabilitation interventions and ultimately contribute to more effective post-stroke rehabilitation strategies. 

Authors/Disclosures
Yiyun Wang (Cornell Tech)
PRESENTER 		No disclosure on file
No disclosure on file
Kevin A. Mazurek, PhD (Mayo Clinic) Dr. Mazurek has received personal compensation for serving as an employee of Delos Living / Well Living Lab. Dr. Mazurek has received intellectual property interests from a discovery or technology relating to health care. An immediate family member of Dr. Mazurek has a non-compensated relationship as a Editor with Â鶹´«Ã½Ó³»­ Resident and Fellows Section that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.
Ania Busza, MD, PhD (University of Rochester) Dr. Busza has received research support from NIH/NINDS. Dr. Busza has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH.