Abstract Details

Title Higher HDL and ApoA Apolipoproteins are Associated with Better Cerebral Perfusion in Multiple Sclerosis Patients

Topic Multiple Sclerosis

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 9-012

Objective

To determine associations between lipid profile measures and cerebral perfusion-based indices in MS patients.

Background Multiple sclerosis (MS) progression and neurodegeneration has been associated with abnormal lipid profile. The mechanism through which these associations interact is currently unknown.

Design/Methods

Seventy-seven MS patients underwent blood draw for lipid profile quantification and 3T MRI. Diagnostic reagent and immunoturbidometric kits were used to determine total cholesterol, low and high-density lipoprotein cholesterol (LDL-C and HDL-C) and levels of apolipoprotein AI, AII, B, CII and E. Dynamic susceptibility contrast (DSC) perfusion-weighted imaging (PWI) produced global and regional measures of cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT). CBV and CBF measures were normalized as perfusion ratio of gray matter (GM) to normal-appearing white matter (NAWM). PWI-based measures of normal-appearing brain tissue (NABT), GM, cortex, deep gray matter (DGM) and thalamus were also calculated. Age and body mass index (BMI)-adjusted correlations determined associations between PWI and lipid profile measures. Bootstrapping calculated 95% confidence intervals.

Results Higher HDL-C levels were associated with shorter MTT, which indicates greater perfusion (NABT, p=0.012; NAWM, p=0.021; GM, p=0.009; cortex, p=0.014; DGM, p=0.015; and thalamus, p=0.015). Similarly, higher levels of ApoA-I and ApoA-II were associated with shorter MTT of the same brain regions (p<0.028). Conversely, higher levels of ApoC-II and ApoE levels were associated with lower cortical nCBV of the GM and cortex (p<0.035). Moreover, higher ApoC-II was associated with lower nCBF in the cortex (p=0.036), DGM (p=0.027), and thalamus (p=0.028).

Conclusions

Higher HDL and HDL-associated apolipoproteins are associated with better global brain perfusion as measured by shorter MTT. On the other hand, higher ApoC-II and ApoE may be associated with lower cortical and DGM perfusion.

Authors/Disclosures
Dejan Jakimovski, MD, PhD (Buffalo Neuroimaging Analysis Center, University at Buffalo) PRESENTER	Dr. Jakimovski has nothing to disclose.
Murali Ramanathan, PhD (University At Buffalo)	The institution of Dr. Ramanathan has received research support from DoD. Dr. Ramanathan has received publishing royalties from a publication relating to health care.
Michael G. Dwyer III, MD, PhD (Buffalo Neurological Analysis Center)	Dr. Dwyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Keystone Heart, Ltd. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Dwyer has received research support from Novartis. The institution of Dr. Dwyer has received research support from Keystone Heart, Ltd. The institution of Dr. Dwyer has received research support from Bristol Myers Squibb. The institution of Dr. Dwyer has received research support from Roche.
Niels Bergsland (Buffalo Neuroimaging Analysis Center / State University of New York At Buffalo)	Prof. Bergsland has nothing to disclose.
	No disclosure on file
	No disclosure on file
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo)	Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Robert Zivadinov, MD, PhD, F�鶹��ýӳ�� (Buffalo Neuroimaging Analysis Center)	The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Myrobalan. Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.

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