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Abstract Details

Alteration of Resting-state Functional Connectivity in Response to Structural Disruption Differs Between Well-Established Functional Networks in Multiple Sclerosis
Multiple Sclerosis
P2 - Poster Session 2 (8:00 AM-9:00 AM)
9-011
To characterize the relationship between structural and functional connectivity within and between common resting-state networks (RSNs) in people with multiple sclerosis (PwMS).
Clinical heterogeneity in PwMS is often attributed to multifarious patterns of structural disruption (SD). However, there is a gap in knowledge as to how SD relates to functional connectivity (FC) alterations in PwMS. Moreover, it is unknown how consistent this relationship is across the various functional networks within the brain.
Structural and resting-state functional MRI were obtained from 73 PwMS and 50 healthy controls, which were processed to measure SD and deviations in FC. A general linear model was applied to quantify the relationship between SD and deviati    ons in FC relative to controls. These relationships were assessed for 10 common RSNs by comparing FC deviations in pairs of regions with both regions entirely within network (intranetwork) or with one region within the network connected to an outside region (internetwork).
In the context of intranetwork connectivity, moderate associations of SD with FC changes were observed in the right-hemisphere frontoparietal (RHFP, R2 = 0.210, p = 0.005), executive control (R2 = 0.173, p = 0.007), and default mode (DMN, R2 = 0.160, p < 0.001) networks. In contrast the weakest associations were observed in the sensorimotor (R2 = 0.071, p = 0.034), early visual (V1/V2; R2 = 0.060/ 0.054, p = 0.157/ 0.155), and left hemisphere frontoparietal (LHFP, R2 = 0.072, p = 0.009) networks. Similar associations were observed in the context of internetwork connectivity.
Specific functional networks differ in their relative association between functional and structural connectivity at the network level. The default mode and other “higher-order” networks appear most functionally sensitive to SD, and there appears to be substantial lateralization of this relationship in the fronto-patieral networks.
Authors/Disclosures
Alexander Bartnik
PRESENTER 		No disclosure on file
Tom Fuchs (Buffalo Neuroimaging Analysis Center) Mr. Fuchs has nothing to disclose.
No disclosure on file
No disclosure on file
Matthew R. Mallory No disclosure on file
No disclosure on file
Zachary Weinstock Mr. Weinstock has nothing to disclose.
Niels Bergsland (Buffalo Neuroimaging Analysis Center / State University of New York At Buffalo) Prof. Bergsland has nothing to disclose.
No disclosure on file
Bianca Weinstock-Guttman, MD (Department of Neurology, University At Buffalo) Dr. Weinstock-Guttman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Novartis . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genzyme &Sanofi. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen . Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bayer. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Horizon. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Weinstock-Guttman has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen. Dr. Weinstock-Guttman has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Janssen. Dr. Weinstock-Guttman has received personal compensation in the range of $0-$499 for serving as a Reviewer with NIH.
Ralph H. Benedict, PhD (University At Buffalo) Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Benedict has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bristol Meyers Squibb. Dr. Benedict has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunic Therapeutics. Dr. Benedict has received intellectual property interests from a discovery or technology relating to health care.
Robert Zivadinov, MD, PhD, FÂ鶹´«Ã½Ó³»­ (Buffalo Neuroimaging Analysis Center) The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Omnicuris. The institution of Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Myrobalan. Dr. Zivadinov has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi. Dr. Zivadinov has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for EMD Serono. Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bristol Myers Squibb. The institution of Dr. Zivadinov has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Biogen.
Michael G. Dwyer III, MD, PhD (Buffalo Neurological Analysis Center) Dr. Dwyer has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bristol Myers Squibb. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Keystone Heart, Ltd. Dr. Dwyer has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. The institution of Dr. Dwyer has received research support from Novartis. The institution of Dr. Dwyer has received research support from Keystone Heart, Ltd. The institution of Dr. Dwyer has received research support from Bristol Myers Squibb. The institution of Dr. Dwyer has received research support from Roche.