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Abstract Details

Sleep Dependent Memory Consolidation in People With Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
P2 - Poster Session 2 (8:00 AM-9:00 AM)
12-004
We hypothesized that sleep would not benefit memory retention in people with epilepsy.
People with epilepsy commonly report long-term memory difficulties. However, the underlying mechanisms of these deficits are unknown. The hierarchical nesting of slow oscillations, spindles, and ripples during slow wave sleep (SWS) has been proposed to provide the temporal framework for consolidation of long-term memory by shuttling the newly formed memories from the hippocampus to the neocortex. All of these classes of neural oscillations are also impacted by epilepsy. We hypothesized that sleep would not benefit memory retention in people with epilepsy.
To test it, we compared the epilepsy patients’ (n=5) performance on a sleep-sensitive verbal memory task over two conditions, sleep and wakeful retention intervals. The study had two phases – learning and retrieval. We used a Paired-Associated Learning (PAL) task, which assesses verbal declarative learning (left hippocampus) and proven to be sensitive to effects of sleep. Subjects were tested immediately after the learning phase (criterion trial) and also after a two-hour “nap” retention interval on the sleep day, and a two-hour period of wakefulness on a control day.
“Retention Performance” was defined by the percentage of recalled word pairs during the retrieval test, with performance on the criterion trial was set to 100%. All of the participants had some periods of SWS during the “nap” retention interval; however, the “Retention Performance” was not significantly different between the sleep and wakeful conditions (p-value>0.05).
We demonstrated that unlike what reported in people without epilepsy, SWS did not benefit memory retention in people with epilepsy. We proposed that sleep-dependent memory consolidation is impaired in epilepsy patients and may underlie their long-term memory deficits. We hope that through the interventions during deep sleep, we will be able to enhance memory consolidation and improve long-term memory in people with epilepsy.
Authors/Disclosures
Fatemeh Khadjevand, MD, MPH (Tufts Medical Center)
PRESENTER 		Dr. Khadjevand has nothing to disclose.
No disclosure on file
Laura A. Cinski, MD (Inova Neurology) No disclosure on file
Erik K. St. Louis, MD (Mayo Clinic) The institution of Dr. St. Louis has received research support from NIH. Dr. St. Louis has received publishing royalties from a publication relating to health care. Dr. St. Louis has received publishing royalties from a publication relating to health care.
Gregory A. Worrell, MD (Mayo Clinic College of Medicine) Dr. Worrell has received stock or an ownership interest from NeuroOne Inc.. Dr. Worrell has received stock or an ownership interest from Cadence Neuroscience Inc. The institution of Dr. Worrell has received research support from NIH. The institution of Dr. Worrell has received research support from Medtronic Inc.. The institution of Dr. Worrell has received research support from Neuropace Inc,. The institution of Dr. Worrell has received research support from Epilepsy Foundation of America. Dr. Worrell has received intellectual property interests from a discovery or technology relating to health care. Dr. Worrell has received intellectual property interests from a discovery or technology relating to health care.