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Abstract Details

Accuracy of Magnetic Resonance Angiography for Identifying Moderate to Severe Internal Carotid Artery Stenosis: Analysis of CREST trial
Cerebrovascular Disease and Interventional Neurology
P2 - Poster Session 2 (8:00 AM-9:00 AM)
4-004
We performed this study to identify the accuracy of MRA in the setting of a multi center clinical trial in identifying moderate to severe Internal Carotid Artery stenosis. 
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We analyzed the data collected as part of CREST trial. Patients were eligible for randomization if Magnetic Resonance Angiogram (MRA) demonstrated 70-99% stenosis or 80-99% stenosis in symptomatic and asymptomatic patients. We determined the accuracy and positive predictive value of MRA demonstrated stenosis 70-99% in severity for identifying severe (70-99%) and moderate to severe (50-99%) ICA stenosis. 
A total of 650 of 2522 patients underwent a MRA and 405 patients had ipsilateral ICA stenosis 70-99% on MRA. Cerebral angiograms were performed in 957 of 2522 patients who had 70-99% stenosis demonstrated by MRA. Cerebral angiography identified 70-99% and 50-99% ICA stenosis in 147 (15.36%) and 210 (21.94%) of patients, respectively. The positive predictive value of MRA demonstrated 70-99% stenosis was 73.36% for identifying 70-99% stenosis and 70.29% for identifying 50-99% stenosis by cerebral angiography. 

The accuracy of Magnetic Resonance Angiogram demonstrated 70-99% stenosis was modest in setting of multicenter clinical trial for identifying severe and moderate to severe stenosis demonstrated by cerebral angiography
Authors/Disclosures
Maryum Shoukat, MD
PRESENTER 		Dr. Shoukat has nothing to disclose.
Hamza I. Maqsood, MD (Dept of Neurology) Dr. Qureshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca.