Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Classic and overlapping Miller Fisher syndrome: Clinical and electrophysiological features
General Neurology
P16 - Poster Session 16 (5:30 PM-6:30 PM)
6-008
1. To describe the clinical and electrophysiological features of patients with Miller Fisher syndrome (MFS). 2. To compare them between patients with classic and overlapping MFS.

Classic and overlapping MFS usually have divergent clinical courses. Data in this regard is nevertheless limited and comes from different settings. In addition, few studies have addressed the electrophysiological evaluation of patients with MFS, and most of them have been carried out in Asia. Due to previous limitations, this study was conducted.
Patients with MFS were identified from our cohort (n=142). Both classic and overlapping MFS were defined following the criteria suggested by Wakerley and colleagues. Electrodiagnosis was made according to the criteria proposed by Hadden and colleagues. Clinical, biochemical and electrodiagnostic parameters were described and then compared between groups. Antiganglioside antibodies were not tested.

20 (14%) patients from our cohort had MFS (15 males, aged 42.2±13.6 years). They were further classified into classic (n=8, 5.6%) and overlapping MFS (n=12, 8.4%). Of these patients, 10 (83%) had overlap with Guillain-Barré syndrome (GBS) and 2 (16%) with Bickerstaff brainstem encephalitis (BBE). No difference was found in age and gender distribution between classic and overlapping MFS. Hospital stay, use of immunomodulation, and CSF protein levels were significantly higher in those with overlapping MFS (11 [0-53] vs 1 [0-34] days, IVIg: 6 vs 0,  42 [20-101] vs 38 [22-83] mg/dL, respectively). 15 patients (75%) underwent nerve conduction studies: 4 patients with classic MFS were classified as equivocal. 9 patients with MFS/GBS were classified as AIDP (n=5), AMAN (n=2), AMSAN (n=1) and equivocal (n=1), respectively. 2 patients with MFS/BBE were classified as AMSAN (n=1) and equivocal (n=1), respectively. 
Almost 15% of the patients in our cohort had MFS; more than half of them had overlapping MFS. The most common overlap syndrome was MFS/GBS, specifically MFS/AIDP.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
Roberto Cervantes Uribe, MD (Centro Medico Naval) No disclosure on file
Edwin S. Vargas, MD (National Institute of Neurology, Mexico) Dr. Vargas has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Sanofi. Dr. Vargas has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for CSL Berhing.