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Abstract Details

Hepatic Reflections in Brain: The Clinicoradiological Spectrum
General Neurology
P16 - Poster Session 16 (5:30 PM-6:30 PM)
6-001
To study the imaging spectrum of neurological complications in various liver diseases 
Liver plays a major role in detoxification. Disturbance in the liver-brain axis occurring in liver disease is attributed to several factors like poor detoxification, persistently elevated levels of neurotoxins and portosystemic shunting .Array of neurological disturbances occurs due to resultant damage to brain cells. These neurological syndromes range from those associated with liver disease may manifest as complication of primary liver disease (cirrhosis, hepatic encephalopathy), or from conditions that affect both liver and nervous system (Wilsons disease), those induced by a contributory factors (alcohol), metabolic derangement or may be superimposed to underlying liver disease. Pertinent neuroimaging features of these entities were observed. 

Methodology –Observational Study.

Duration – 3 yrs( July 2016- June 2019) 
Total no of 183 patients were included in the study. Diversity in the clinical presentations and neuroimaging features are seen in the various liver diseases such as Wilsons disease (46) and alcoholism related neurological complications [ cerebral (24)and cerebellar atrophy (38), Wernickes encephalopathy (12) , Marchiafava Bignami disease (7), osmotic demyelination (10)] , cirrhosis (4) hepatic encephalopathy(4), hepatic myelopathy (2), Parkisonism due to underling liver cirrhosis (2), intracerebral hemorrhage (3), infections (11), posterior reversible encephalopathy syndrome (15), progressive multifocal leucoencephalopathy(3) and metronidazole induced toxicity (2).Although classic MR imaging abnormalities of liver disease include high signal intensity in the globus pallidum on T1-weighted images, underlying abnormality adds to the plethora of imaging spectrum. Recognition and cognizance of these imaging features in appropriate clinical context is of utmost importance to the radiologist

Awareness and comprehension of radiological appearances of the neurological entities associated with liver diseases in light of clinical presentation prompts diagnosis and is vital in planning therapeutic measures.

Authors/Disclosures

PRESENTER 		No disclosure on file
Suman Kushwaha, MD (Insitute of Human Behavior & Allied Sciences) Dr. Kushwaha has nothing to disclose.
No disclosure on file
No disclosure on file