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Abstract Details

Stroke and Death Rate in Patient Cohort Studies of Extracranial Vertebral Artery Stenosis: A Systematic Review
Cerebrovascular Disease and Interventional Neurology
P16 - Poster Session 16 (5:30 PM-6:30 PM)
4-010
To Ascertain Rates of Stroke, Transient Ischemic Attack (TIA) and All-Cause Death in Patients with Extracranial Vertebral Artery Stenosis.
Vertebral artery (VA) stenosis is one of the major causes of TIA and ischemic stroke in posterior circulation. Second most common area of stenosis of extracranial VA is the proximal part. In hospital setting, incidence of ischemic stroke is greater in patients with extracranial VA stenosis than other areas (annual-rate, 0.4% vs. 0.1%). However, the extracranial VA stenosis has not been well studied as a risk factor for stroke recurrence in patients with acute ischemic stroke, exclusively for posterior circulation ischemic stroke.
Online search was conducted using MEDLINE and Pubmed database with the keywords “extracranial vertebral artery disease”, “stroke”, “TIA” or “death”. Filters such as “cohort studies” OR “case-control studies”, “retrospective”, “incidence”, “prognosis”, “mortality” OR “follow-up/follow-up studies” AND “clinical trials”. Database was searched from 2000 to 2018. All studies which provided rates of stroke and death during the follow-up period were included in the study. Data analysis was performed using IBM Corp. IBM SPSS statistics.
Our initial search identified 266 articles out of which 27 articles were included after removing duplicates and those articles which didn't meet inclusion criteria. Total sample size was 1811 patients derived from 27 included studies. Mean number of participants per study was 67 with a minimum of 10 and maximum of 282 patients followed over a mean follow-up period of 2.4 (±SD 1.3) years. Incidence of stroke was 21.9 events per 1000 person-year (95%-CI 14.6 - 30.9), TIA or stroke was 46.3 events per 1000 person-year (95%-CI 35.4-60.2), and all-cause mortality was 14.7 events per 1000 person-year (95%-CI 9.1-22.2).
A relatively high rate of incident stroke and death was seen in patients with extracranial VA stenosis highlighting the need for further clinical studies in this patient population.
Authors/Disclosures
Ahmer Asif, MD
PRESENTER 		Dr. Asif has nothing to disclose.
Omar Saeed, MD Dr. Saeed has nothing to disclose.
Hamza I. Maqsood, MD (Dept of Neurology) Dr. Qureshi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for AstraZeneca.