Abstract Details Title The combined presence of hypertension and vitamin D deficiency increased the probability of the occurrence of small vessel disease in China Topic Cerebrovascular Disease and Interventional Neurology Presentation(s) P16 - Poster Session 16 (5:30 PM-6:30 PM) Poster/Presentation Number 4-015 Objective The aim of this study was to determine the exact association between 25(OH) D and small vessel disease (SVD) in China. Background Whether the effect of 25(OH)D on SVD could be modified by the history of hypertension needs to be further elucidated in China. We hypothesized there might be some relationships between 25(OH)D deficiency and the occurrence of SVD in China. Design/Methods We retrospectively enrolled 106 patients with SVD and 115 controls between Jan and Dec 2017. They were categorized into three subgroups according to the level of 25 (OH) D: vitamin D deficiency (< 12 ng/ml), insufficiency (12-20 ng/ml) and sufficiency (> 20 ng/ml). Results Among 106 SVD patients, 80 (75.5%) were men and the mean age was 61.6 ± 13.2 years. The deficiency of 25(OH) D was observed in 76 (71.7%) of SVD patients and 47 (40.9%) of controls (P = 0.001). Compared with controls, patients with SVD were more likely to be male, a stroke history, smokers, with hyperlipidemia, higher systolic and diastolic blood pressure and low-density lipoprotein, and lower of 25(OH)D level (P < 0.05). Logistic regression analysis revealed the level of 25 (OH) D as an independent predictor of SVD (OR 0.772, 95% CI 0.691-0.862, P = 0.001). Compared with the sufficient 25 (OH) D group, the ORs of SVD in deficient and insufficient 25(OH)D group were 5.609 (95% CI 2.006-15.683) and 1.077 (95% CI: 0.338-3.428) after adjusting for potential confounders, respectively. In hypertensives with vitamin D deficient and insufficient group compared with sufficient group, the ORs of SVD increased to 9.738 (95% CI 2.398-39.540) and 1.108 (95% CI 0.232-5.280), respectively (Pinteraction = 0.001). Conclusions We found significant associations between SVD and 25(OH)D deficiency. The combined presence of hypertension and vitamin D deficiency increased the probability of developing SVD. Our findings will warrant further prospective studies in the future. Authors/Disclosures Junliang Yuan, Sr., MD (Beijing chaoyang hospital) PRESENTER No disclosure on file