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Abstract Details

Progression from Mild Cognitive Impairment to Dementia in an Essential Tremor Cohort
Movement Disorders
P15 - Poster Session 15 (12:00 PM-1:00 PM)
3-002
To quantify the rate of progression from mild cognitive impairment (MCI) to dementia in a cohort of essential tremor (ET) cases. 
ET is among the most common neurological diseases. Non-motor features, including various levels of cognitive dysfunction, have been associated with ET. Yet much of our knowledge of the cognitive impairment in ET is of the static condition (e.g., prevalence of cognitive impairment), with nearly no information on its dynamics (i.e., course and clinical outcomes). As such, the conversion rate from MCI to dementia has not been quantified in ET. 
168 research ET cases, enrolled in a prospective, longitudinal, clinical-pathological study, underwent an extensive battery of motor-free neuropsychological testing. The results of these assessments informed clinical diagnoses of normal cognition (ET-NC), MCI (ET-MCI), and dementia (ET-D). Cases were evaluated over three intervals:  baseline (T1), 1.5 years (T2), and 3 years (T3). 

At baseline, 29 cases (82.6 ± 7.2 years) were diagnosed with ET-MCI and were available for follow-up at T2. At T2, three of these 29 (10.3%) had converted to ET-D. At the start of T2, a total of 30 cases were diagnosed with ET-MCI and were available for follow-up at T3. At T3, eight of 30 (26.6%) converted to ET-D. The average annual conversion rate from ET-MCI to ET-D was 12.3%. Historically, the rate of conversion in similarly-aged control individuals in the general population is 2.6 – 6.3%.

The study of cognitive impairment in ET is a nascent field, with limited data. Here we showed that the rate of conversion from MCI to dementia is elevated in a cohort of ET cases. Data such as these systematically fill gaps in knowledge and create a scientifically-derived knowledge base to guide physicians, patients, and families in clinical settings.

Authors/Disclosures
Elan D. Louis, MD, MS, FÂ鶹´«Ã½Ó³»­ (University of Texas Southwestern Medical Center)
PRESENTER 		Dr. Louis has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Wolters Kluwer - Merritt's Textbook of Neurology. Dr. Louis has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Legal Firm. The institution of Dr. Louis has received research support from National Institutes of Health. Dr. Louis has received publishing royalties from a publication relating to health care. Dr. Louis has a non-compensated relationship as a Board of Directors with International Essential Tremor Foundation that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Louis has a non-compensated relationship as a Medical Advisory Board with HopeNET that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.
No disclosure on file
No disclosure on file
No disclosure on file
Tess E. Cersonsky Ms. Cersonsky has nothing to disclose.
Stephanie Cosentino, PhD (Columbia University Medical Center) Dr. Cosentino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Association for Frontotemporal Dementia. Dr. Cosentino has received personal compensation in the range of $500-$4,999 for serving as a Consultant for SAGE Pharmaceuticals.