Abstract Details

Title Association between Helicobacter pylori Infection and Stroke: A Systematic review and Meta-analysis of Observational Studies

Topic General Neurology

Presentation(s) P15 - Poster Session 15 (12:00 PM-1:00 PM)

Poster/Presentation
Number 6-002

Objective This systematic review and meta-analysis aimed to investigate the association between helicobacter pylori (HP) and stroke.

Background Stroke is the fifth leading cause of mortality worldwide. Several modifiable risk factors for ischemic stroke were identified. However, current risk factors do not sufficiently explain it, especially in young people. Hence, the interest to identify other risk factors of stroke is uprising. Several studies suggest the presence of an association between infections and stroke; including infection with HP.

Design/Methods The protocol was registered in PROSPERO (CRD42019123689). Four electronic search engines/libraries were systematically searched for relevant observational studies. Studies were screened for eligibility and data were extracted. The odds ratio (OR) and 95 % con?dence interval (95 % CI) were combined under the random-effect model.

Results Among the included studies for our analysis, 25 studies were for anti-HP IgG, nine studies for anti-Cag A and six studies for the C-urea breath test. The results showed that positive anti-HP IgG was signi?cantly associated with increased risk of stroke [OR (95 % CI) = 1.43 (1.25–1.46)]. Similarly, both results of anti-Cag A and C-urea breath test were signi?cantly associated with increased risk of stroke with [OR (95 % CI) = 1.77 (1.25–2.49) ] for anti-Cag A and [OR (95 % CI) = 2.21 (1.33–3.66) ] for C-urea breath test. Furthermore, our results indicated that positive anti-HP IgG was associated with stroke caused by atherothrombosis and small artery disease.

Conclusions Our study suggests that HP infection is associated with stroke. However, more studies are required to investigate whether HP eradication may help stroke patients or not for future clinical application.

Authors/Disclosures
Mohamed Fahmy Doheim (University of Pittsburgh) PRESENTER	Mr. Doheim has nothing to disclose.
	No disclosure on file
	No disclosure on file
Alaa A. Elshinbary III, Ms (Bin Ladin Group)	Ms. Elshinbary has nothing to disclose.
Amira A. Aboali, MD (Department of Diagnostic and Interventional Radiology, Damanhour Teaching Hospital, General Organisation for Teaching Hospitals and Institutes, Damanhour, Egypt.)	Dr. Aboali has nothing to disclose.
Toqa Mahmoud Dahy	No disclosure on file
Mahmoud Dibas, MD	Mr. Dibas has nothing to disclose.
	No disclosure on file

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Abstract Details