Âé¶¹´«Ã½Ó³»­

Âé¶¹´«Ã½Ó³»­

Explore the latest content from across our publications

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Neurosarcoidosis with Radiographic Findings Consistent with CLIPPERS
Autoimmune Neurology
P15 - Poster Session 15 (12:00 PM-1:00 PM)
15-005
We present a case of Neurosarcoidosis with radiographic findings of CLIPPERS.
Neurosarcoidosis is CNS or PNS involvement seen in 5 - 10 % of patients with sarcoidosis. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is an encephalomyelitis that preferentially involves the pons and cerebellum. Radiographic findings in neurosarcoidosis  are classically smooth leptomeningeal and nodular parenchymal enhacement on T1 contrast imaging. CLIPPERS presents with multiple punctate regions of T1 contrast enhancement in the pons and cerebellum. CLIPPERS is responsive to long term glucocorticoid therapy whereas Neurosarcoidosis requires long term immunosuppressive therapy.
N/A

We present a case of a 46 year old male who presented with sudden onset intractable headache. The patient reported the headache began abruptly and at maximal intensity approximately 4 months prior to examination. This headache was associated with episodes of severe vertigo lasting seconds to minutes. The patient underwent imaging which showed extensive punctate enhancement involving the structures in the posterior fossa, most pronounced in the vermis of the cerebellum. The patient underwent lumbar puncture which showed significantly elevated protein at 225 mg/dL, 125 WBC at 90% lymphocytes, 16 RBCs, and decreased glucose of 24 mg/dL and negative oligoclonal bands. The patient underwent extensive testing for aseptic meningitis to rule out a viral, tuberculous, or neoplastic etiology. CT scan of the chest was performed which showed mild hilar lymphadenopathy which was subsequently biopsied and demonstrated non-necrotizing granulomatous inflammation. The patient was started on methotrexate and prednisone for definite neurosarcoidosis per Zajicek criteria.


CLIPPERS is an inflammatory  encephalomyelitis with classic radiographic findings of punctate pontine and cerebellar enhancement. Concurrent autoimmune disease such as sarcoidosis may obscure diagnosis and delay or prevent treatment of CLIPPERS. 
Authors/Disclosures
Ali Y. Mohamud, MD
PRESENTER
No disclosure on file