Abstract Details

Title Intrusions in episodic memory in preclinical autosomal dominant Alzheimer’s disease: Contributions of education and occupation to optimal recall

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P15 - Poster Session 15 (12:00 PM-1:00 PM)

Poster/Presentation
Number 10-009

Objective To determine the contributions of education and occupational attainment to optimal memory recall in a cohort of young cognitively unimpaired individuals with autosomal dominant Alzheimer’s disease.

Background In this study we analyze clinical and cognitive data from members of the Colombian kindred with autosomal dominant AD due to the E280A mutation in the presenilin-1 (PSEN1) gene. This cohort offers a unique opportunity to examine preclinical changes in young individuals with no age-related comorbidities. Evaluation of cognitive performance in cognitively unimpaired mutation carriers offers a window to characterize some of the earliest memory and functional changes associated with the disease.Intrusions in episodic memory recall have been shown to be greater in subjects with mild cognitive impairment and sporadic Alzheimer’s disease. Intrusions have been hypothesized to be a failure in inhibitory processes that support successful encoding and retrieval of previously learned information.

Design/Methods In this cross-sectional study we analyzed sociodemographic factors and clinical and cognitive data from a group of 310 mutation carriers of the PSEN1 mutation and examined the relationship among education, occupational attainment and the MMSE, CERAD word list learning and delayed recall, and word list intrusions.

Results Occupation was not significantly associated with clinical and cognitive measures when controlling for education. However, education was significantly associated with all measures, including when controlling for occupation: higher educational level was significantly correlated with better performance on MMSE (r=.28, p=.001), memory total word recall (r=.35, p=.001) and delayed recall (r=.33, p=.001), and with lower number of intrusions during both immediate and delayed recall (r= -.15, p=.01).

Conclusions These results suggest that in preclinical E280A mutation carriers performance on episodic memory was worse among those with lower educational attainments. Low education was also correlated with a higher number of intrusions in episodic memory suggesting that their recall was less optimal.

Authors/Disclosures
Liliana A. Ramirez-Gomez, MD, F�鶹��ýӳ�� (Wang Ambulatory Care Center) PRESENTER	The institution of Dr. Ramirez-Gomez has received research support from NIA-NIH.
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Claudia A. Munoz, MD, MPH (Vituity)	No disclosure on file
	No disclosure on file
	No disclosure on file
Francisco J. Lopera Restrepo, MD, PhD (Universidad De Antioquia)	No disclosure on file
Yakeel Quiroz, PhD	Dr. Quiroz has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. The institution of Dr. Quiroz has received research support from National Institutes of Health. The institution of Dr. Quiroz has received research support from Alzheimer's Association. The institution of Dr. Quiroz has received research support from Mass General Hospital Executive Committee on Research (ECOR). Dr. Quiroz has received intellectual property interests from a discovery or technology relating to health care.

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