Abstract Details

Title Body mass index and leptin are associated with executive function over 10 years in women with and without HIV infection. The Women’s Interagency HIV Study (WIHS)

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P14 - Poster Session 14 (8:00 AM-9:00 AM)

Poster/Presentation
Number 10-007

Objective Body Mass Index (BMI), leptin, and 10y change in BMI and leptin, were related to executive function (EF) in WIHS participants with (HIV+) and at risk for HIV infection (HIV-).

Background BMI and the obesity hormone, leptin are related to cognition in HIV+ and HIV- adults. EF is a key cognitive domain affected.

Design/Methods BMI, leptin, 10y change in BMI and leptin, and tests of EF in 301 HIV+ and 113 HIV- WIHS participants (age 39.8+/-9.2y) were included. Measures were: 1) EF via Trails B and Stroop Interference tests; 2) BMI (kg/m²); and 3) plasma leptin (ng/ml) via Millipore ELISA. Analyses were run in the entire sample and by HIV status. T-tests estimated differences in BMI and leptin by HIV status and 2 visits 10 years apart. Multivariate linear regression analyses predicted EF T-score by baseline and 10y change in leptin and BMI. SAS 9.4 was used.

Results

Over 10 years, from mean age 40-50y, HIV+ and HIV- women transitioned from overweight (29.1+/-7.9 kg/m²) to obese (30.4+/-7.9 kg/m²) BMI. Leptin increased (11.4+/-26.4 ng/ml). Baseline BMI and leptin predicted lower EF 10 years later in HIV- women (BMI beta=-0.368, SE=0.099, p <0.001; leptin beta=-0.134 SE=0.038, p=0.001). Among HIV+ women, 10y increases in BMI and leptin predicted lower EF score (BMI beta=-0.383, SE=0.16, p=0.019; leptin beta=-0.071, SE=0.025, p=0.006) adjusted for HIV viral load and CD4+.

Conclusions During the fifth decade of life in HIV+ and HIV- women, associations between anthropometric and metabolic obesity measures, BMI and leptin, differ in associations with later EF by HIV status. Among HIV- women, higher baseline BMI and leptin levels at age 40y predicted poorer EF performance at age 50y; greater 10y increases in BMI and leptin levels predicted poorer EF in HIV+ women. Variability in leptin and other obesity factors over time may predict cognition.

Authors/Disclosures
Francesca Macaluso PRESENTER	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
	No disclosure on file
Deborah Gustafson, PhD, MS	The institution of Deborah Gustafson, PhD, MS has received research support from National Institutes of Health.

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Abstract Details