Age range of symptom onset was 19-69 years with a mean of 48 years. A Male to Female ratio of 19:15 was observed with 84%(29/34) Caucasian,6%(2/34) African-American, 3%(1/34) Asian, and 3%(1/34)Hispanics. Type II-Diabetes was found in 19%(6/34) with the age of symptom onset being 55 years. The age of onset in non-diabetic patients was 44.5 years. Sensory symptoms at onset were symmetric in 93%(29/34), bilateral foot involvement only in 68%(21/34),simultaneous hand and foot involvement in 26%(8/34), persistent in 58%(18/34), and exacerbated by physical activity in 87%(31/34). In patients whose symptoms started in their feet with subsequent hand involvement, on average 6.5 years elapsed. Excluding patients with diabetes or other pain syndromes,40%(10/26) endorsed issues with balance and fine hand movements. Prescription medication for neuropathic pain was used in 71% (25/34) of patients, 19%(7/34) of which were on two. Excluding patients with restless leg syndrome, 74%(16/21) reported symptoms interfered with sleep. A positive family history for neuropathy was found in 35%(14/34)

In our patients with TS-HDS antibodies we noted predominantly painful sensory symptoms that started in the feet with subsequent hand involvement and exacerbation by physical activity. Sleep disturbance was also common. These clinical findings are comparable with existing literature. We noted that the age of symptom onset in non-diabetics was 10.5 years earlier than diabetics. While it was known from prior studies that diabetes is less common in TS- HDS population than controls, the age of onset was not compared. Further research is needed to study the relation between TS – HDS polyneuropathy and diabetes