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Abstract Details

Hyperperfusion in the cerebellum in patients with epileptic seizures
Epilepsy/Clinical Neurophysiology (EEG)
P13 - Poster Session 13 (5:30 PM-6:30 PM)
12-003
To investigate cerebellar perfusion in patients with epileptic seizures using arterial spin labeling perfusion magnetic resonance image (ASL). 
The cerebellum plays an important role in motor control however its involvement in epilepsy has not been fully understood. ASL is a noninvasive method to evaluate cerebral (and cerebellar) blood flow.

 Eight patients with epileptic seizures who underwent ASL in three post labeling delay (PLD) conditions (1525, 1800 and 2500 ms) and conventional electroencephalography (EEG) on the same day were included. Clinical and EEG characteristics of them were retrospectively analyzed.
Six patients (6 women, age; 36.2 ± 17.9 years (mean ± SD)) showed hyperperfusion in selective areas the cerebellar paravermis of lobule VIIB. In one patient with generalized epilepsy (tentative diagnosis of juvenile myoclonic epilepsy or epilepsy with myoclonic absences) showed unilateral hypoperfusion in PLD 1525 ms and hyperperfusion in PLD 1800 and 2500 ms at the area while EEG showed generalized spike-wave complex. In two patients with focal epilepsy manifesting with asymmetrical motor symptoms, cerebellar hyperperfusion was found on the opposite side to the seizure focus estimated by seizure semiology.
The cerebellar paravermis of lobule VIIB can be a component of motor circuit and participate in epileptic functional network in humans.
Authors/Disclosures
Masako Kinoshita, MD, PhD (8 Ondoyamacho)
PRESENTER 		Dr. Kinoshita has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Otsuka Pharmaceutical Co., Ltd.. Dr. Kinoshita has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Eisai Co., Ltd.. Dr. Kinoshita has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for UCB Japan Co. Ltd. . Dr. Kinoshita has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Daiichi Sankyo Company, Limited.. The institution of Dr. Kinoshita has received research support from Japan Society for the Promotion of Science. The institution of Dr. Kinoshita has received research support from Nakatani Foundation for Advancement of Measuring Technologies in Biomedical Engineering .
No disclosure on file
Kaoru Obata, MD No disclosure on file
No disclosure on file
No disclosure on file