Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Chronic Painin the Wearing Off Phase of Parkinson's Disease
Pain
P12 - Poster Session 12 (12:00 PM-1:00 PM)
6-001
To evaluate the relationship between chronic pain and wearing-off in Parkinson's disease patients.
Pain is a frequent non-motor symptom that can emerge years before motor symptoms in Parkinson’s disease. Pain during WO phase appears to be related to low levels of dopamine and the analysis of its characteristics could help in understanding the pathophysiology of pain in patients with PD.

34 patients with idiopathic PD under levodopa therapy were selected.  The diagnosis of WO was made using the Wearing Off Questionnaire (WOQ-19) and theUnified Prkinson’s Disease Rating Scale(UPDRS-III), which were applied during both ON and OFF phases. Levodopa treatment complications were evaluated by the UPDRS-IV. Pain was assessed using the McGill Pain Questionnaire (MPQ). The diagnosis of neuropathic pain was performed by LANSS Scale (Leeds assessment of neuropathic symptoms and signs). Only the most significant pain and with a minimum of 3 months duration was included in the analysis.
Chronic pain was found in 61.8% of patients, 47.6% of these showed pain during WO (WOP) and 52,4% showed pain in other moment not WO (NWOP). The most prevalent type of pain was the musculoskeletal, and the lower limbs was the most frequently affected. WO was found in 82.3% of patients, proving to be a risk factor for the development of chronic pain (P=0.021). The score on the UPDRS-IV was higher in patients with chronic pain, suggesting a higher frequency of treatment complications in this group (P=0.027). There were no differences in relation to PD characteristics between the WOP and NWOP groups. Pain was relieved by levodopa administration in 90% of WOP patients, demonstrating the association between pain and low levels of dopamine in that period.
Patients with WOP had higher scores in the affective/motivational pain dimension (P=0.022), strengthening the hypothesis of a role of dopamine in the affective pain perception.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
Helio Afonso G. Teive, MD, PhD, FÂ鶹´«Ã½Ó³»­ Dr. Teive has nothing to disclose.
No disclosure on file
Carlos Henrique F. Camargo, MD, PhD, MSc, FÂ鶹´«Ã½Ó³»­ (Inovare Serviços de Saude Ltda.) Dr. Camargo has nothing to disclose.