The aim of the study was to analyze Vitamin D receptor (VDR) gene sequence and to find connections between it's mutations and prevalence of several PD side effects including levodopa-induced dyskinesia, depression, UPDRS scale score, Hoehn and Yahr scale score and dementia (MMSE).

Parkinson’s disease (PD) is second most often occuring neurodegenerative disease after Alzheimer’s disease. Age is being considered the most important factor for PD risk. Vitamin D(VD) is an steroid hormone crucial for calcium homeostasis and bone metabolism. . VD metabolism is multi-factorial process which involves specific enzymes of liver and kidneys with 1,25-D3 being active product. Latest research indicates that VD modulates over 1000 genes involved in cellular growth, protein synthesis and immunological processes. Several animal studies have shown potential protective attributes of VD in dopamine cells.

Sequential analysis of VDR gene was performed on genomic DNA isolated from peripheral blood leukocytes of 100 patients with diagnosed Parkinson’s Disease treated with Levodopa.  Sequencing was performed in 3130xl Genetic Analyzer(Applied Biosystems) and statistical analysis was conducted using AB DNA Sequencing Analysis Software v. 5.2.(Applied Biosystems).

We conclude that due to connections between VDR Gene mutations and clinical consequences gene sequencing may serve as an viable way to predict future Parkinson Disease course, thus allowing to optimize potential therapeutic plan.