A total of 290 subjects (migraine [n=195], tension-type headache [n=54], probable migraine [n=21] and non-headache [n=20]) participated in this investigation.  Subjects completed quantitative measures of misophonia (Misophonia Assessment Questionnaire [MAQ]), trypophobia (Trypophobia Image Score [TIS], modified Lee, Cole and Wilkins Trypophobia Score [mLCWTS]) and TES (Emotional Response to Various Surfaces Score [ERVSS]) in addition to associated disability (Migraine Disability Assessment Scores [MIDAS] and cutaneous allodynia (Allodynia Symptom Checklist [ASC-12]).

Average MIDAS were 0.2, 1.4, 51, 23 and 77 for non-headache (NH), tension-type headache (TTH), all migraine (M), episodic migraine (EM) and chronic migraine (CM) respectively.  Average ASC-12 scores were <0.5 in NH and TTH groups and 5.7 (M), 5.3 (EM) and 6.0 (CM).  The measure of misophonia (MAQ) showed average scores <0.7 in NH and TTH.  Elevated average MAQ scores of 7.7, 6.2 and 9.1 were seen in M, EM and CM respectively.  Trypophobia indicators (TIS/mLCWTS) were lower in NH (0.3/18) and TTH (0.2/17) as compared to M (1.2/21), EM (1.2/20) and CM (1.3/21).  Average ERVSS, a measure of TES, were significantly higher in the M (2.3), EM (2.4) and CM (2.3) versus NH (0.5) and TTH (0.6). 

Clinical measures for LSS were elevated in subjects with M compared to those with NH or TTH; CM more so than EM.  These findings suggest that within the migraine matrix, dynamic changes may lead to limbic system sensitization like known to occur in trigeminal and thalamic structures.