Abstract Details

Title Serum NfL Predicts Hemorrhage Recurrence In Cerebral Amyloid Angiopathy-Related Hemorrhage

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P12 - Poster Session 12 (12:00 PM-1:00 PM)

Poster/Presentation
Number 4-018

Objective This study aims to explore the value of blood-based biomarkers for predicting intracerebral hemorrhage (ICH) recurrence in patients with cerebral amyloid angiopathy (CAA).

Background So far, the prediction of ICH recurrence for CAA mostly rely on imaging features and few focus on the blood-based biomarkers.

Design/Methods We recruited patients with first CAA-ICH between January 2014 and August 2018 from a Chinese prospective cohort with clinical, imaging and regular follow-up data. Sixteen kinds of acute phase blood biomarkers covering β-amyloid deposition and secondary vascular and neural damage were measured with high-sensitive single-molecule array or Luminex assays. Independent clinical and biomarker predictors of ICH recurrence in CAA were identified by multivariate Cox model and evaluated by Concordance index (C-index). The associations of potential predictors with disease severity and clinical outcome were also analyzed.

Results A total of 68 CAA-ICH patients with mean age of 70.1 years and male 73.5% were recruited. During a median follow-up of 2.1 years, recurrent ICH occurred in 17 patients (25.0%). In CAA patients, the clinical model of total MRI burden of small vessel disease (SVD) predicted ICH recurrence risk best (C-index of 0.768, 95% confidence interval [CI], 0.604-0.932). Among 16 blood biomarkers, serum neurofilament light chain (NfL) was the only independent predictor of recurrent ICH (hazard ratio 2.101 [95% CI, 1.515-2.912], p<0.001), increasing C-index of predictive model to 0.875 (95% CI, 0.711-1.000). Further, NfL was associated with ICH lesion volume (coefficient 4.503, p=0.025), baseline NIHSS score (OR 1.678, p=0.002) and 6-month mRS score (OR=1.748, p=0.002) in multivariate analysis.

Conclusions

Acute phase serum NfL complementary to total MRI burden of SVD is a promising biomarker for the prediction of ICH recurrence and clinical outcome in CAA-ICH.

Authors/Disclosures
YA SU, MD (Huashan Hospital, Fudan University) PRESENTER	No disclosure on file
Xin Cheng (Haushan Hospital)	No disclosure on file
QIANG DONG, PhD (Huashan Hospital Fudan University)	No disclosure on file

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Abstract Details