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Abstract Details

Effects of 5-HTTLPR Polymorphisms on Amygdalar Functional Connectivity and Emotional Regulation
Aging, Dementia, and Behavioral Neurology
P12 - Poster Session 12 (12:00 PM-1:00 PM)
10-001

The objectives of this study are twofold: 1) To review and analyze the literature comparing the effects of 5-HTTLPR polymorphisms on amygdalar functional connectivity, and 2) to elucidate the effect of circuitry variation on emotional regulation.
5-HTTLPR is located in the promotor region of the serotonin transporter protein gene, which is responsible for recycling serotonin. It has been theorized that polymorphisms in this region may affect functional connectivity between various brain regions and the amygdala, which has been associated with fear and other emotional responses. The short (S) allele polymorphism of 5-HTTLPR has been associated with maladaptive traits linked to mood disorders.
This systematic review employed predetermined inclusion/exclusion criteria to select relevant studies from various databases. Two independent reviewers conducted title and abstract screening on 7,504 articles obtained from the preliminary search results. Full-text screening was then conducted on all remaining articles. Themes were identified through commonalities between and within the final 16 manuscripts, and the data will be tabulated for reporting and analysis using a modified version of the Cochrane Data Extraction and Assessment Template form. The final studies have also been subjected to quality assessment using the Joanna Briggs Institute Critical Appraisal Checklist.
Preliminary results support the association of the S allele with maladaptive emotional processing and traits linked to depression and anxiety. The maladaptive traits were also associated with variations in amygdalar functional connectivity related to 5-HTTLPR. Major connections involved the fusiform gyrus, anterior cingulate cortex, insula, and prefrontal cortex, which are responsible for facial processing and emotional regulation.
Mood disorders have arbitrary diagnostic methodology and few treatment options with limited efficacy. Variations among 5-HTTLPR genotypes and the changes in functional connectivity they produce may provide a measurable phenotype upon which diagnosis and treatment can be based.
Authors/Disclosures
Danielle A. Reynolds, MD (Yale New Haven Hospital)
PRESENTER 		Dr. Reynolds has nothing to disclose.
Aimen Vanood, MD (Mayo Clinic Arizona) Dr. Vanood has nothing to disclose.
No disclosure on file