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Abstract Details

Effects of Aerobic Exercise Training on Carotid Arterial Stiffness and Brain Health in Traumatic Brain Injury
Neuro Trauma, Critical Care, and Sports Neurology
P11 - Poster Session 11 (8:00 AM-9:00 AM)
5-005
To evaluate the feasibility to conduct a structured aerobic exercise training (AET) protocol in patients with chronic traumatic brain injury (TBI), particularly focusing on arterial stiffness and neuropsychological function.
AET has been shown to improve vascular and brain health in healthy adults, although its effect remains unclear in patients with TBI. Our previous cross-sectional study showed that TBI patients have higher carotid arterial stiffness compared with healthy age-matched adults. We hypothesized that AET also improves cardiorespiratory fitness, decreases carotid arterial stiffness, and further improves brain health in patients with TBI.
Seventeen TBI survivors (10 mild and 7 moderate-to-severe; age: 48±13 years, 10 women) with persistent neurological symptoms 6-60 months after initial injury were recruited and randomized to 3-month moderate-intensity AET or control stretching program. Cardiorespiratory fitness was assessed by peak oxygen uptake (VO2peak) using a modified Astrand-Saltin treadmill protocol. Carotid arterial compliance was measured as an inverse index of arterial stiffness using ultrasonography and applanation tonometry. Neuropsychological function was assessed using the NIH Toolbox. 
Ten participants were randomized to AET group and seven to stretching group. No age, gender, VO2peak, or cognition performance differences were noted at baseline. Although no statistically significant changes were observed following the intervention, different trends were observed. VO2peak increased by 7% in AET yet decreased by 4% in stretching; arterial compliance increased by 12 % in AET and decreased by 2% in stretching; NIH Toolbox fluid composite score improved by 15% in AET and 9% in stretching; and the NIH Toolbox total composite score improved by 7% in AET versus 4% in stretching.
Our findings suggest the potential benefits of AET and provide preliminary information for power analysis and the design of a large-scale clinical trial to determine the brain health benefits of AET following TBI.
Authors/Disclosures
Tran B. Le, MD
PRESENTER 		Dr. Le has nothing to disclose.
Tsubasa Tomoto, PhD Dr. Tomoto has nothing to disclose.
No disclosure on file
Munro Cullum, PhD (Univ of Texas Southwestern Medical Center) The institution of Dr. Cullum has received research support from NIH. Dr. Cullum has received intellectual property interests from a discovery or technology relating to health care. Dr. Cullum has received personal compensation in the range of $10,000-$49,999 for serving as a Scientific Director with Texas Alzheimers Research and Care Consortium.
No disclosure on file
No disclosure on file
Marisara Dieppa, MD (University of Texas SW Medical School) Dr. Dieppa has nothing to disclose.
Kan Ding, MD (UT Southwestern Medical Center) The institution of Dr. Ding has received research support from National Institute of Aging. The institution of Dr. Ding has received research support from NINDS.