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Abstract Details

Objective Markers of Foot Tapping in Idiopathic Parkinson’s Disease with Freezing of Gait
Movement Disorders
P11 - Poster Session 11 (8:00 AM-9:00 AM)
3-009
To develop quantitative measures of foot bradykinesia in idiopathic Parkinson’s disease (PD).
Motor blocks occur in Parkinson’s disease (PD) patients during speech, upper limb movements (such as handwriting and repetitive finger tapping) and lower limb movements (gait and repetitive foot tapping). While freezing of gait (FOG) is the most studied of these phenomena, determination of temporal changes in brain connectivity using fMRI or EEG is limited due to motion artifact during active gait. Quantitative measures of lower limb function that correlate with gait would therefore help.
PD patients with FOG and without (noFOG), and healthy controls (HC) were consented after IRB approval. Subjects walked 8 lengths of a 20’x4’ Zeno pressure sensor impregnated mat (Protokinetics) in their medication ON state at a comfortable pace and fast pace. Subjects wore tri-axial accelerometers (APDM) while performing alternating bipedal foot tapping for 20s at a comfortable and fast pace. Gait and foot tapping spatiotemporal dynamics were extracted.
15 HC and 30 PD patients (14 noFOG and 16 FOG) were analyzed. Age, disease duration, Hoehn & Yahr scores and motor and total UPDRS scores were similar between the PD groups. Foot tapping velocity (comfortable pace) was faster (HC 1.3±0.4, noFOG 1.5±0.4, FOG 1.8±0.5 taps/s; p=0.010 HC vs FOG) and inter-tap interval was shorter (HC 0.8±0.2, noFOG 0.7±0.2, FOG 0.6±0.2 s; p=0.016 HC vs FOG) in FOG subjects. Foot tapping amplitude was smaller in FOG subjects but not statistically significant (HC 13.3±5.0, noFOG 12.1±4.1, FOG 9.5±5.6 degrees; p=0.054 HC vs FOG). Foot tapping velocity was inversely correlated with stride velocity (Pearson's correlation coefficient -0.624, p=0.010) while inter-tap interval was correlated with stride length (0.561, 0.024).
Foot tapping impairment in PD FOG patients correlated with changes in traditional measures of gait impairment and could serve as non-gait markers of a FOG phenotype.
Authors/Disclosures
Aliyah J. Glover (UAMS Neurology)
PRESENTER 		Miss Glover has nothing to disclose.
Lakshmi Pillai (University of Arkansas for Medical Sciences Little RoCK) Ms. Pillai has nothing to disclose.
Hafsa Bareen Syeda, MBBS (UAMS) Dr. Syeda has nothing to disclose.
Aaron S. Kemp, PhD (University of Arkansas for Medical Sciences) Aaron Kemp has nothing to disclose.
Mitesh P. Lotia, MD (AdventHealth Neuroscience Institute) Dr. Lotia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Lotia has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Orphalan. Dr. Lotia has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbott.
No disclosure on file
Tuhin Virmani, MD, PhD, FÂ鶹´«Ã½Ó³»­ (University of Arkansas for Medical Sciences) The institution of Dr. Virmani has received research support from Parkinson's Foundation.