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Abstract Details

The UCSD Performance-based Skills Assessment Primarily Measures Attention, Executive Function, and Memory in Parkinson’s Disease
Movement Disorders
P11 - Poster Session 11 (8:00 AM-9:00 AM)
3-012
Evaluate relationships between neuropsychological testing and performance-based functional assessment in Parkinson’s disease (PD), in order to move toward more integrated cognitive testing in this population.

Paper-and-pencil neuropsychological testing is limited in its ability to measure functional abilities related to cognition; therefore, functional assessments have been developed and validated for these purposes. However, relationships between cognitive functional abilities and more traditionally defined neuropsychological domains, such as memory and executive function, are poorly defined. In PD, in particular, in which daily function could be limited by cognitive or motor symptoms, there is even less known about these relationships.

100 PD participants completed neuropsychological batteries, UCSD Performance-Based Skills Assessment (UPSA), and UPDRS III motor examination. Cognitive domain scores were calculated for 14 cognitive tests and Pearson correlations between these and UPSA scores examined. The predictive relationship of neuropsychological performance with UPSA score as an outcome was tested with multiple linear regression, controlling for relevant covariates (age, education, disease duration, UPDRS III score).  
Mean age of participants was 67.9 ± 7.1 years, with disease duration of 5.1 ± 5.7 years, and mean MoCA score of 26.5 ± 2.9. UPSA scores correlated significantly with all cognitive domain scores, though most strongly with tests of attention (r=0.57, p<0.001), executive function (r=0.52, p<0.001), and memory (r=0.51, p<0.001). Multivariately, neuropsychological performance and covariates explained 39.3% of the variance in UPSA score (F(9,90)=6.48, p<0.001). After controlling for covariates, UPSA score was predicted only by attention (β=3.35, p=0.004) and memory (β=3.41, p=0.001) cognitive domain scores.  
Performance on the UPSA is most strongly associated with performance on attention, executive, and memory neuropsychological tests in PD, which is important for interpreting UPSA results and understanding its utility as an outcome measure. However, neuropsychological test results did not completely explain UPSA performance, indicating objective functional assessment offers additional useful cognitive information in PD.  
Authors/Disclosures
Samantha K. Holden, MD, MS, FÂ鶹´«Ã½Ó³»­ (University of Colorado School of Medicine)
PRESENTER 		The institution of Dr. Holden has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cognition Therapeutics.
No disclosure on file
Luis D. Medina, PhD (University of Houston) The institution of Dr. Medina has received research support from National Institutes of Health. Dr. Medina has received personal compensation in the range of $500-$4,999 for serving as a Speaker with AbbVie. Dr. Medina has a non-compensated relationship as a Council Member with Alzheimer's Association that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.