Abstract Details

Title Electroencephalographic (EEG) Findings in N-Methyl-D-Aspartase (NMDA) Encephalitis

Topic Autoimmune Neurology

Presentation(s) P11 - Poster Session 11 (8:00 AM-9:00 AM)

Poster/Presentation
Number 15-002

Objective To describe EEG characteristics in a cohort of patients with NMDA encephalitis.

Background NMDA encephalitis is an immune-mediated encephalitis that is classically paraneoplastic to an ovarian teratoma. Diagnosis is based on a combination of unique clinical findings, along with the presence of NMDA antibodies in cerebrospinal fluid and/or blood. EEG is often helpful in the diagnostic phase of the disease, as particular patterns are more suggestive of NMDA encephalitis versus other causes of encephalopathy. In particular, the "delta brush" pattern is thought to be highly specific to the diagnosis of NMDA encephalitis. In the present study, we describe EEG findings in a cohort of NMDA patients.

Design/Methods Single-centre, retrospective study.

Results A total of 27 patients with NMDA encephalitis (confirmed by cerebrospinal fluid testing) were included in the study. 86 EEGs were retrospectively analyzed, with only 1 (1.1%) was within normal limits. No electrographic seizures were observed in any of the EEGs. 10 EEGs (11.6%) showed delta brush. 2 EEGs (2.3%) showed delta brush. The remaining EEGs showed mixed patterns of symmetric and asymmetric slowing, often in the delta range.

Conclusions The delta brush pattern was rarely (11.6%) seen in our cohort, with the most common finding being diffuse slowing in the delta band. Only 1 EEG was normal, suggesting that EEG is a sensitive test for NMDA encephalitis.

Authors/Disclosures
Dustin M. Anderson, MD PRESENTER	No disclosure on file
Nabeela Nathoo, MD, PhD	Dr. Nathoo has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis.
Jeffrey D. Jirsch, MD (University of Alberta)	No disclosure on file

�鶹��ýӳ��

�鶹��ýӳ��

Abstract Details